LRRC71: Leucine-Rich Repeat-Containing Protein 71
A poorly characterized gene encoding a leucine-rich repeat protein with potential roles in protein-protein interactions and cellular signaling.
Gene Information Card
| Symbol | LRRC71 |
|---|---|
| Full Name | Leucine Rich Repeat Containing 71 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 149830 ncbi.nlm.nih.gov/gene/149830 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q8N6N3 |
| OMIM ID | 617706 |
| HGNC ID | 26421 |
| Aliases | FLJ32709, MGC16384 |
Description
LRRC71 (Leucine Rich Repeat Containing 71) is a protein-coding gene located on chromosome 1q32.1. The encoded protein contains leucine-rich repeats (LRRs), which are structural motifs typically involved in protein-protein interactions, signal transduction, and immune responses. The precise biological function of LRRC71 remains incompletely understood, but it is predicted to participate in cellular signaling pathways. Expression data suggest broad but low-level expression across multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.8 | Low |
| Brain | 1.5 | Low |
| Lung | 1.2 | Low |
| Liver | 0.9 | Not detected |
| Kidney | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.0 | Low expression |
| HeLa | 0.8 | Low expression |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) |
Protein Summary
The LRRC71 protein (UniProt Q8N6N3) is 648 amino acids long and contains multiple leucine-rich repeat domains. These repeats are predicted to mediate specific protein-protein interactions. The protein is localized to the cytoplasm and possibly the plasma membrane. No enzymatic activity has been experimentally demonstrated. Structural predictions suggest a horseshoe-shaped solenoid fold typical of LRR proteins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC71 Knockout HEK293 Cell Line | EDJ-KQ11139 | Human | 149499 | Details Get a Quote |
| LRRC71 Knockout HeLa Cell Line | EDJ-KQ58634 | Human | 149499 | Details Get a Quote |
| LRRC71 Knockout A-549 Cell Line | EDJ-KQ67116 | Human | 149499 | Details Get a Quote |
| LRRC71 Knockout HCT 116 Cell Line | EDJ-KQ75522 | Human | 149499 | Details Get a Quote |
