LRRC26: Leucine-Rich Repeat-Containing Protein 26
A regulatory subunit of BK potassium channels with roles in cancer and neuronal signaling
Gene Information Card
| Symbol | LRRC26 |
|---|---|
| Full Name | Leucine Rich Repeat Containing 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.13 |
| NCBI Gene ID | 389816 ncbi.nlm.nih.gov/gene/389816 |
| Ensembl ID | ENSG00000184792 |
| UniProt ID | Q5T4F4 |
| OMIM ID | 617207 |
| HGNC ID | 28585 |
| Aliases | BK channel gamma subunit, KCNMB4 |
Description
LRRC26 encodes a leucine-rich repeat-containing protein that functions as a gamma subunit of the large-conductance calcium-activated potassium (BK) channel. It modulates the voltage and calcium sensitivity of BK channels, particularly in non-excitable cells. LRRC26 is implicated in cancer cell proliferation and neuronal excitability.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | LRRC26 mutations may alter BK channel activity, affecting cell proliferation and migration. | COSMIC database reports somatic mutations in multiple cancer types. |
| Epilepsy | Altered BK channel regulation by LRRC26 may contribute to neuronal hyperexcitability. | ClinVar lists variants associated with neurological phenotypes. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Kidney | 2.1 | Low |
| Prostate | 1.5 | Low |
| Testis | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| HeLa | 1.2 | Low expression |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional effect |
| c.454G>A (p.Gly152Ser) | Missense | <0.01% | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Not established for LRRC26; no confirmed loss-of-function variants reported.
Gain of Function (GOF)
Not established; some missense variants may alter BK channel gating but evidence is limited.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • delayed rectifier potassium channel activity (GO:0005251) | • potassium channel regulator activity (GO:0015459) |
| • plasma membrane (GO:0005886) | • voltage-gated potassium channel complex (GO:0008076) |
Pathways
• Potassium channels (Reactome: R-HSA-1296071)
• Voltage gated Potassium channels (KEGG: hsa04010)
Protein Summary
LRRC26 is a 334-amino acid protein with multiple leucine-rich repeats. It associates with the BK channel alpha subunit (KCNMA1) to form a functional channel complex. The protein is predominantly localized to the plasma membrane and modulates channel opening probability. Expression is low in most tissues, with highest levels in brain and heart.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRRC26 Knockout HEK293 Cell Line | EDJ-KQ14124 | Human | 389816 | Details Get a Quote |
| LRRC26 Knockout HeLa Cell Line | EDJ-KQ44045 | Human | 389816 | Details Get a Quote |
| LRRC26 Knockout A-549 Cell Line | EDJ-KQ68570 | Human | 389816 | Details Get a Quote |
| LRRC26 Knockout HCT 116 Cell Line | EDJ-KQ76946 | Human | 389816 | Details Get a Quote |
