LRP11: LDL Receptor Related Protein 11
A member of the low-density lipoprotein receptor family involved in endocytosis and signaling
Gene Information Card
| Symbol | LRP11 |
|---|---|
| Full Name | LDL Receptor Related Protein 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q25.1 |
| NCBI Gene ID | 84918 ncbi.nlm.nih.gov/gene/84918 |
| Ensembl ID | ENSG00000124782 |
| UniProt ID | Q5T7N2 |
| OMIM ID | 610764 |
| HGNC ID | 19689 |
| Aliases | MGC14836, bA350J20.1 |
Description
LRP11 (LDL Receptor Related Protein 11) is a protein-coding gene belonging to the low-density lipoprotein receptor family. The encoded protein is involved in receptor-mediated endocytosis and may play a role in lipid metabolism and cellular signaling. LRP11 is expressed in multiple tissues and has been implicated in various cancers and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Altered LRP11 expression may affect lipoprotein uptake and signaling pathways in hepatocytes | PMID: 25691885 |
| Colorectal cancer | LRP11 overexpression correlates with tumor progression and poor prognosis | PMID: 29228537 |
| Alzheimer's disease | LRP11 may modulate amyloid-beta clearance via LRP family interactions | PMID: 23382691 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Lung | 6.1 | Low |
| Brain | 4.7 | Low |
| Heart | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| A549 | 7.8 | Lung adenocarcinoma cell line |
| HEK293 | 5.4 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.01% | p.Pro412Ser; predicted benign |
| c.567G>A | Nonsense | <0.01% | p.Trp189*; loss of function |
| c.890_891insA | Frameshift | 0.005% | p.Thr297fs; truncated protein |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Trp189*, p.Thr297fs) lead to premature termination and loss of LRP11 function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in LRP11.
Dominant Negative (DN)
No evidence of dominant-negative effects for LRP11 mutations.
View complete mutation data：
Gene Ontology (GO)
| • low-density lipoprotein particle receptor activity (GO:0005041) | • receptor-mediated endocytosis (GO:0006898) |
| • integral component of membrane (GO:0016021) | • plasma membrane (GO:0005886) |
| • lipid metabolic process (GO:0006629) |
Pathways
• Endocytosis (KEGG: hsa04144)
• Lipoprotein metabolism (Reactome: R-HSA-174824)
Protein Summary
LRP11 encodes a 777-amino acid type I transmembrane protein with multiple ligand-binding repeats characteristic of the LDL receptor family. The protein localizes to the plasma membrane and mediates endocytosis of lipoprotein particles. It is expressed in liver, kidney, and other tissues, and its dysregulation is associated with cancer and neurodegenerative diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRP11 Knockout HEK293 Cell Line | EDJ-KQ3274 | Human | 84918 | Details Get a Quote |
| LRP11 Knockout A-549 Cell Line | EDJ-KQ24822 | Human | 84918 | Details Get a Quote |
| LRP11 Knockout HCT 116 Cell Line | EDJ-KQ24823 | Human | 84918 | Details Get a Quote |
| LRP11 Knockout HeLa Cell Line | EDJ-KQ24824 | Human | 84918 | Details Get a Quote |
