LRP10: LDL Receptor Related Protein 10
A key player in endocytosis, amyloid precursor protein processing, and neurodegenerative disease risk.
Gene Information Card
| Symbol | LRP10 |
|---|---|
| Full Name | LDL Receptor Related Protein 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 26020 ncbi.nlm.nih.gov/gene/26020 |
| Ensembl ID | ENSG00000100804 |
| UniProt ID | Q7Z4F1 |
| OMIM ID | 609921 |
| HGNC ID | 6693 |
| Aliases | LRP9, MST087, LRP-10, MGC138234 |
Description
LRP10 (LDL Receptor Related Protein 10) encodes a member of the low-density lipoprotein (LDL) receptor family. The protein functions as an endocytic receptor involved in the cellular uptake of ligands, including apolipoprotein E (ApoE) and amyloid precursor protein (APP). LRP10 is widely expressed, with highest levels in the brain, and plays a critical role in lipid metabolism, neuronal signaling, and the clearance of amyloid-beta peptides. Genetic variants in LRP10 have been associated with an increased risk of Alzheimer's disease and Parkinson's disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer's disease | Impaired endocytosis of APP and ApoE leads to increased amyloid-beta accumulation | ClinVar, NCBI |
| Parkinson's disease | Loss-of-function variants disrupt lysosomal trafficking and alpha-synuclein clearance | ClinVar, OMIM |
| Cerebral amyloid angiopathy | Dysfunctional LRP10 reduces clearance of amyloid-beta from the brain vasculature | NCBI, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.5 | High |
| Brain (cerebellum) | 10.8 | High |
| Liver | 6.2 | Medium |
| Kidney | 5.1 | Medium |
| Lung | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 14.2 | Neuronal model |
| HEK293 (embryonic kidney) | 8.7 | Common overexpression system |
| HepG2 (hepatocellular carcinoma) | 6.0 | Hepatic expression |
| U87MG (glioblastoma) | 11.3 | Glial cell model |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.142C>T (p.Arg48Cys) | Missense | Rare | Reduced ligand binding and endocytosis |
| c.512G>A (p.Arg171His) | Missense | Rare | Impaired APP trafficking |
| c.1063G>A (p.Val355Met) | Missense | Rare | Decreased cell surface expression |
| c.1528C>T (p.Arg510Cys) | Missense | Rare | Loss of function in lysosomal pathway |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., p.Arg48Cys, p.Arg510Cys) reduce receptor internalization and ligand clearance, leading to amyloid-beta accumulation.
Gain of Function (GOF)
No gain-of-function mutations have been reported for LRP10.
Dominant Negative (DN)
Heterozygous missense mutations may exert dominant-negative effects by forming non-functional dimers with wild-type LRP10.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Alzheimer disease - amyloid-beta clearance pathway (Reactome: R-HSA-977225)
• LDL receptor-mediated endocytosis (Reactome: R-HSA-8866423)
• Lipoprotein metabolism (KEGG: hsa04979)
Protein Summary
LRP10 is a 777-amino acid transmembrane protein belonging to the LDL receptor family. It contains ligand-binding type A repeats, an EGF-like domain, a transmembrane domain, and a cytoplasmic NPxY motif essential for endocytosis. The protein is primarily localized to the plasma membrane and endosomes, where it mediates the internalization of ligands such as ApoE and APP. LRP10 is highly expressed in neurons and glial cells, and its dysfunction is linked to impaired amyloid-beta clearance and neurodegeneration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LRP10 Knockout HEK293 Cell Line | EDJ-KQ8356 | Human | 26020 | Details Get a Quote |
| LRP10 Knockout A-549 Cell Line | EDJ-KQ34385 | Human | 26020 | Details Get a Quote |
| LRP10 Knockout HCT 116 Cell Line | EDJ-KQ34386 | Human | 26020 | Details Get a Quote |
| LRP10 Knockout HeLa Cell Line | EDJ-KQ34387 | Human | 26020 | Details Get a Quote |
