LPAR5 (Lysophosphatidic Acid Receptor 5)
G protein-coupled receptor for lysophosphatidic acid signaling
Gene Information Card
| Symbol | LPAR5 |
|---|---|
| Full Name | lysophosphatidic acid receptor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 57121 ncbi.nlm.nih.gov/gene/57121 |
| Ensembl ID | ENSG00000184574 |
| UniProt ID | Q9H1C0 |
| OMIM ID | 606949 |
| HGNC ID | 13308 |
| Aliases | GPR92, LPA5, KPG_010, GPR93 |
Description
LPAR5 (lysophosphatidic acid receptor 5) encodes a G protein-coupled receptor (GPCR) that binds lysophosphatidic acid (LPA), a bioactive phospholipid. The receptor couples primarily to Gq/11 and G12/13 proteins, mediating cellular responses such as proliferation, migration, and cytoskeletal rearrangement. LPAR5 is involved in neuropathic pain, cancer progression, and immune modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuropathic pain | LPAR5 activation in dorsal root ganglia neurons enhances pain signaling via Gq/PLC pathway | PMID: 21278728 |
| Colorectal cancer | Overexpression promotes cell migration and invasion through Rho/ROCK signaling | PMID: 25636850 |
| Breast cancer | LPA-LPAR5 axis stimulates metastasis via PI3K/Akt pathway | PMID: 27323850 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Brain | 4.2 | Low |
| Liver | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression in recombinant systems |
| A549 (lung cancer) | 9.7 | Endogenous expression |
| MCF7 (breast cancer) | 7.4 | Moderate expression |
| HCT116 (colorectal cancer) | 11.3 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Unknown functional impact |
| c.784A>G (p.Ile262Val) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• LPA signaling via G protein-coupled receptors (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Rho GTPase cycle (Reactome: R-HSA-194840)
Protein Summary
LPAR5 is a 372-amino acid integral membrane protein with seven transmembrane domains typical of class A GPCRs. It binds extracellular LPA with high affinity, activating Gq/11 and G12/13 pathways to stimulate phospholipase C, Rho GTPases, and MAP kinases. The protein is expressed in immune tissues, small intestine, and certain cancers, where it modulates cell motility and survival.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPAR5 Knockout HEK293 Cell Line | EDJ-KQ1289 | Human | 57121 | Details Get a Quote |
| LPAR5 Knockout HCT 116 Cell Line | EDJ-KQ19344 | Human | 57121 | Details Get a Quote |
| LPAR5 Knockout A-549 Cell Line | EDJ-KQ20688 | Human | 57121 | Details Get a Quote |
| LPAR5 Knockout HeLa Cell Line | EDJ-KQ20690 | Human | 57121 | Details Get a Quote |
