LPAR4
Lysophosphatidic Acid Receptor 4
Gene Information Card
| Symbol | LPAR4 |
|---|---|
| Full Name | Lysophosphatidic Acid Receptor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq21.1 |
| NCBI Gene ID | 2846 ncbi.nlm.nih.gov/gene/2846 |
| Ensembl ID | ENSG00000147133 |
| UniProt ID | Q99677 |
| OMIM ID | 300042 |
| HGNC ID | 4518 |
| Aliases | GPR23, LPA4, P2RY9 |
Description
LPAR4 (Lysophosphatidic Acid Receptor 4) encodes a G protein-coupled receptor (GPCR) that binds lysophosphatidic acid (LPA), a bioactive phospholipid. It is involved in cell proliferation, migration, and differentiation. LPAR4 is expressed in various tissues and has been implicated in cancer progression and cardiovascular development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | LPAR4 signaling via G12/13 and Gq pathways promotes cell migration and invasion | PMID: 23444367 |
| Cardiovascular disease | LPAR4 regulates vascular development and angiogenesis | PMID: 23395169 |
| Neuropathic pain | LPA signaling through LPAR4 contributes to pain sensitization | PMID: 21518877 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Lung | 15.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 10.4 | Medium |
| Testis | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical cancer cell line |
| A549 | 14.2 | Lung cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| HEK293 | 22.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | 0.01% | Altered ligand binding |
| c.452G>A (p.Arg151His) | Missense | 0.005% | Unknown functional effect |
| c.784C>T (p.Arg262Cys) | Missense | 0.002% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Mutations that impair receptor activation or G protein coupling, e.g., p.Arg262Cys.
Gain of Function (GOF)
Not well characterized; some variants may enhance signaling.
Dominant Negative (DN)
Not reported for LPAR4.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • lysophosphatidic acid receptor activity |
| • cell surface receptor signaling pathway | • positive regulation of cell migration |
| • angiogenesis |
Pathways
• LPA signaling pathway
• GPCR downstream signaling
• G12/13 signaling events
• Gq signaling
Protein Summary
LPAR4 is a 370-amino acid transmembrane GPCR that couples to G12/13 and Gq proteins. Upon LPA binding, it activates Rho and PLC signaling, influencing cytoskeletal rearrangements and gene expression. It is expressed in multiple tissues and plays roles in development, immune response, and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPAR4 Knockout HEK293 Cell Line | EDJ-KQ834 | Human | 2846 | Details Get a Quote |
| LPAR4 Knockout HeLa Cell Line | EDJ-KQ53399 | Human | 2846 | Details Get a Quote |
| LPAR4 Knockout A-549 Cell Line | EDJ-KQ61876 | Human | 2846 | Details Get a Quote |
| LPAR4 Knockout HCT 116 Cell Line | EDJ-KQ70357 | Human | 2846 | Details Get a Quote |
