LPAR1: Lysophosphatidic Acid Receptor 1
A G protein-coupled receptor for lysophosphatidic acid involved in cell proliferation, migration, and survival.
Gene Information Card
| Symbol | LPAR1 |
|---|---|
| Full Name | Lysophosphatidic Acid Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 1902 ncbi.nlm.nih.gov/gene/1902 |
| Ensembl ID | ENSG00000198721 |
| UniProt ID | Q92633 |
| OMIM ID | 602282 |
| HGNC ID | 3167 |
| Aliases | EDG2, LPA1, Gpcr26, rec1.3 |
Description
LPAR1 encodes a G protein-coupled receptor for lysophosphatidic acid (LPA), a bioactive phospholipid. The receptor mediates diverse cellular responses including proliferation, migration, differentiation, and survival. LPAR1 is implicated in cancer progression, fibrosis, neuropathic pain, and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuropathic pain | LPAR1 activation in dorsal root ganglia promotes pain signaling | PMID: 21362587 |
| Pulmonary fibrosis | LPA-LPAR1 signaling drives fibroblast recruitment and collagen deposition | PMID: 18385429 |
| Ovarian cancer | LPAR1 overexpression enhances tumor cell migration and invasion | PMID: 15217926 |
| Breast cancer | LPAR1 promotes metastasis via Rho/ROCK pathway | PMID: 19151778 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Ovary | 6.1 | Low |
| Heart | 4.2 | Low |
| Liver | 2.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| A549 (lung cancer) | 9.5 | Moderate expression |
| MCF7 (breast cancer) | 7.2 | Moderate expression |
| SKOV3 (ovarian cancer) | 11.3 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Reduced receptor activity |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Altered ligand binding |
| c.784C>T (p.Arg262Cys) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Arg34Trp reduces LPA-induced signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described for LPAR1.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • lysophosphatidic acid receptor activity |
| • cell surface receptor signaling pathway | • positive regulation of cell migration |
| • positive regulation of cell proliferation | • Rho protein signal transduction |
Pathways
• LPA signaling via GPCRs
• RhoA/ROCK pathway
• PI3K/Akt pathway
• MAPK/ERK pathway
Protein Summary
LPAR1 is a 364-amino acid integral membrane protein with seven transmembrane domains. It couples primarily to Gαi/o and Gαq/11 proteins, activating downstream effectors such as Rho, Ras, and PI3K. The receptor is widely expressed in brain, lung, and reproductive tissues, and its dysregulation contributes to fibrotic diseases and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LPAR1 Knockout HEK293 Cell Line | EDJ-KQ832 | Human | 1902 | Details Get a Quote |
| LPAR1 Knockout A-549 Cell Line | EDJ-KQ19610 | Human | 1902 | Details Get a Quote |
| LPAR1 Knockout HCT 116 Cell Line | EDJ-KQ19611 | Human | 1902 | Details Get a Quote |
| LPAR1 Knockout HeLa Cell Line | EDJ-KQ53135 | Human | 1902 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
