LMO4 Gene: LIM Domain Only 4
Transcriptional regulator involved in development and cancer
Gene Information Card
| Symbol | LMO4 |
|---|---|
| Full Name | LIM domain only 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p22.3 |
| NCBI Gene ID | 8543 ncbi.nlm.nih.gov/gene/8543 |
| Ensembl ID | ENSG00000143013 |
| UniProt ID | P61968 |
| OMIM ID | 603129 |
| HGNC ID | 6643 |
| Aliases | LIM-4, LMO-4 |
Description
LMO4 (LIM domain only 4) encodes a protein containing two LIM domains, which are zinc-binding motifs involved in protein-protein interactions. LMO4 acts as a transcriptional regulator by interacting with other transcription factors and co-regulators, playing roles in cell differentiation, proliferation, and development. It is implicated in several cancers, particularly breast cancer, and in neurodevelopment.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of LMO4 promotes cell proliferation and invasion through interaction with BRCA1 and other transcription factors. | PMID: 12524540; COSMIC |
| Oral squamous cell carcinoma | LMO4 upregulation correlates with tumor progression and poor prognosis. | PMID: 18413744 |
| Neurodevelopmental disorders | LMO4 knockout mice show defects in neural tube closure and brain development. | PMID: 15198989 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Kidney | 6.1 | Low |
| Liver | 4.2 | Low |
| Lung | 7.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HeLa (cervical cancer) | 9.8 | Medium expression |
| HEK293 (embryonic kidney) | 6.5 | Low expression |
| HepG2 (liver cancer) | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Potential loss of start codon; effect unknown |
| c.205C>T (p.Arg69Trp) | missense | <0.1% | Rare variant; functional impact uncertain |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in human disease.
Gain of Function (GOF)
Overexpression in breast cancer suggests potential gain-of-function role via increased transcriptional activity.
Dominant Negative (DN)
Not described for LMO4.
View complete mutation data：
Gene Ontology (GO)
Pathways
• BRCA1-associated genome surveillance complex (BASC)
• Notch signaling pathway (via interaction with RBPJ)
Protein Summary
LMO4 is a 165-amino acid nuclear protein containing two LIM domains (LIM1 and LIM2) that mediate protein-protein interactions. It functions as a transcriptional co-regulator, often interacting with LDB1, BRCA1, and other factors to modulate gene expression. LMO4 is essential for normal development and is frequently overexpressed in breast cancer, where it promotes cell proliferation and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMO4 Knockout HEK293 Cell Line | EDJ-KQ6278 | Human | 8543 | Details Get a Quote |
| LMO4 Knockout A-549 Cell Line | EDJ-KQ30174 | Human | 8543 | Details Get a Quote |
| LMO4 Knockout HCT 116 Cell Line | EDJ-KQ30175 | Human | 8543 | Details Get a Quote |
| LMO4 Knockout HeLa Cell Line | EDJ-KQ30176 | Human | 8543 | Details Get a Quote |
