LMNTD2 Gene
Lamin Tail Domain Containing 2
Gene Information Card
| Symbol | LMNTD2 |
|---|---|
| Full Name | Lamin Tail Domain Containing 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 100506142 ncbi.nlm.nih.gov/gene/100506142 |
| Ensembl ID | ENSG00000255302 |
| UniProt ID | A0A1B0GTV4 |
| OMIM ID | - |
| HGNC ID | HGNC:37241 |
| Aliases | C11orf91, bA203J24.7 |
Description
LMNTD2 (Lamin Tail Domain Containing 2) is a protein-coding gene located on chromosome 11p15.4. The encoded protein contains a lamin tail domain, suggesting a potential role in nuclear structure or function. Limited functional characterization is available, and expression data indicate low to moderate levels in select tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | - | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Thyroid | 1.1 | Low |
| Adrenal gland | 0.8 | Low |
| Other tissues | <0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| K562 | 0.1 | Very low expression |
| HeLa | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The LMNTD2 protein is predicted to contain a lamin tail domain, which may be involved in nuclear lamina interactions. However, no experimental validation of its function or subcellular localization is currently available in UniProt or other curated databases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMNTD2 Knockout HEK293 Cell Line | EDJ-KQ11827 | Human | 256329 | Details Get a Quote |
| LMNTD2 Knockout A-549 Cell Line | EDJ-KQ40244 | Human | 256329 | Details Get a Quote |
| LMNTD2 Knockout HCT 116 Cell Line | EDJ-KQ40245 | Human | 256329 | Details Get a Quote |
| LMNTD2 Knockout HeLa Cell Line | EDJ-KQ40246 | Human | 256329 | Details Get a Quote |
