LMAN2L
Lectin, Mannose Binding 2 Like
Gene Information Card
| Symbol | LMAN2L |
|---|---|
| Full Name | Lectin, Mannose Binding 2 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 81562 ncbi.nlm.nih.gov/gene/81562 |
| Ensembl ID | ENSG00000162998 |
| UniProt ID | Q9H0V9 |
| OMIM ID | 609551 |
| HGNC ID | 24808 |
| Aliases | VIP36-like, VIPL, ERGL |
Description
LMAN2L (Lectin, Mannose Binding 2 Like) encodes a type I transmembrane protein localized to the endoplasmic reticulum (ER) and ER-Golgi intermediate compartment. It functions as a lectin that binds high-mannose glycans and facilitates the transport of glycoproteins from the ER to the Golgi apparatus. LMAN2L is homologous to LMAN1 and VIP36, and plays a role in quality control and trafficking of N-linked glycoproteins.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression may affect glycoprotein trafficking and tumor progression | Expression data from COSMIC and literature |
| Breast cancer | Potential role in ER stress and unfolded protein response | Expression data from COSMIC and literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Brain | 8.1 | Low |
| Heart | 7.3 | Low |
| Lung | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 11.2 | Medium expression |
| HepG2 | 13.4 | Medium expression |
| MCF7 | 9.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional impact |
| c.100C>T | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005515 (GO:0005515) | • GO:0005783 (GO:0005783) |
| • GO:0005794 (GO:0005794) | • GO:0006890 (GO:0006890) |
| • GO:0030246 (GO:0030246) |
Pathways
• ER to Golgi vesicle-mediated transport (R-HSA-199977)
• Protein processing in endoplasmic reticulum (KEGG hsa04141)
Protein Summary
LMAN2L is a 356-amino acid type I transmembrane lectin with a luminal carbohydrate recognition domain (CRD) that binds high-mannose oligosaccharides. It cycles between the ER and ER-Golgi intermediate compartment, assisting in the sorting and transport of glycoproteins. The protein is ubiquitously expressed with highest levels in liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMAN2L Knockout HEK293 Cell Line | EDJ-KQ9712 | Human | 81562 | Details Get a Quote |
| LMAN2L Knockout HeLa Cell Line | EDJ-KQ35279 | Human | 81562 | Details Get a Quote |
| LMAN2L Knockout A-549 Cell Line | EDJ-KQ36504 | Human | 81562 | Details Get a Quote |
| LMAN2L Knockout HCT 116 Cell Line | EDJ-KQ36505 | Human | 81562 | Details Get a Quote |
