LMAN2 Gene (Lectin, Mannose Binding 2)
VIP36: A key cargo receptor in the secretory pathway
Gene Information Card
| Symbol | LMAN2 |
|---|---|
| Full Name | Lectin, Mannose Binding 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 10960 ncbi.nlm.nih.gov/gene/10960 |
| Ensembl ID | ENSG00000113140 |
| UniProt ID | Q12907 |
| OMIM ID | 609551 |
| HGNC ID | 6640 |
| Aliases | VIP36, GP36B, C5orf8 |
Description
LMAN2 (Lectin, Mannose Binding 2), also known as VIP36, encodes a type I transmembrane lectin that functions as a cargo receptor in the early secretory pathway. It cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, binding high-mannose-type glycans to facilitate the transport and quality control of glycoproteins. LMAN2 is ubiquitously expressed and plays a role in maintaining ER homeostasis and protein secretion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Congenital disorders of glycosylation (CDG) | LMAN2 mutations may impair glycoprotein trafficking, leading to defective glycosylation patterns. | UniProt; OMIM |
| Cancer (various) | Altered LMAN2 expression has been observed in several cancers, potentially affecting tumor cell glycoprotein secretion and immune evasion. | COSMIC; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 15.2 | Medium |
| Pancreas | 12.8 | Medium |
| Kidney | 10.5 | Medium |
| Heart | 8.3 | Low |
| Brain | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.7 | Cervical cancer cell line |
| HEK293 | 13.2 | Embryonic kidney cells |
| HepG2 | 16.1 | Hepatocellular carcinoma |
| A549 | 11.4 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497G>A (p.Arg166His) | Missense | <0.01% | Uncertain significance; reported in ClinVar |
| c.103C>T (p.Arg35Trp) | Missense | <0.01% | Likely benign; ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in LMAN2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • mannose binding (GO:0005537) |
| • intracellular protein transport (GO:0006886) | • retrograde vesicle-mediated transport (GO:0006890) |
| • integral component of membrane (GO:0016021) | • vesicle coat (GO:0030120) |
| • protein localization to Golgi apparatus (GO:0034067) |
Pathways
• ER-to-Golgi vesicle-mediated transport (Reactome: R-HSA-199977)
• Golgi-to-ER retrograde transport (Reactome: R-HSA-6811442)
• Quality control of glycoproteins (UniProt)
Protein Summary
LMAN2 (VIP36) is a 36 kDa type I transmembrane lectin localized to the ER-Golgi intermediate compartment. It binds high-mannose oligosaccharides on glycoproteins, acting as a cargo receptor for their transport from the ER to the Golgi. The protein contains a luminal carbohydrate recognition domain, a transmembrane region, and a short cytoplasmic tail. It cycles between compartments via COPI and COPII vesicles, contributing to glycoprotein quality control and secretion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LMAN2 Knockout HEK293 Cell Line | EDJ-KQ3721 | Human | 10960 | Details Get a Quote |
| LMAN2L Knockout HEK293 Cell Line | EDJ-KQ9712 | Human | 81562 | Details Get a Quote |
| LMAN2 Knockout A-549 Cell Line | EDJ-KQ25760 | Human | 10960 | Details Get a Quote |
| LMAN2 Knockout HCT 116 Cell Line | EDJ-KQ25761 | Human | 10960 | Details Get a Quote |
| LMAN2 Knockout HeLa Cell Line | EDJ-KQ25762 | Human | 10960 | Details Get a Quote |
| LMAN2L Knockout HeLa Cell Line | EDJ-KQ35279 | Human | 81562 | Details Get a Quote |
| LMAN2L Knockout A-549 Cell Line | EDJ-KQ36504 | Human | 81562 | Details Get a Quote |
| LMAN2L Knockout HCT 116 Cell Line | EDJ-KQ36505 | Human | 81562 | Details Get a Quote |
