LIPM: Lipase Family Member M
A comprehensive resource for LIPM gene information, including genomic data, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | LIPM |
|---|---|
| Full Name | lipase family member M |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.31 |
| NCBI Gene ID | 340204 ncbi.nlm.nih.gov/gene/340204 |
| Ensembl ID | ENSG00000198723 |
| UniProt ID | Q5VXJ0 |
| OMIM ID | 617119 |
| HGNC ID | 23452 |
| Aliases | bA425D10.1, LIPL, LIPM_HUMAN |
Description
LIPM (lipase family member M) is a protein-coding gene located on chromosome 10q23.31. It encodes a member of the lipase family, which hydrolyzes triglycerides into free fatty acids and glycerol. LIPM is expressed in various tissues, particularly in the liver and adipose tissue, and may play a role in lipid metabolism. Mutations in LIPM have been associated with metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertriglyceridemia | Loss of lipase activity leads to impaired triglyceride hydrolysis, causing elevated plasma triglycerides. | ClinVar, OMIM |
| Obesity | Altered LIPM expression may affect lipid storage and energy balance, contributing to obesity. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Adipose Tissue | 8.3 | Medium |
| Small Intestine | 5.1 | Low |
| Pancreas | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| 3T3-L1 | 7.8 | Adipocyte precursor cell line |
| Caco-2 | 4.5 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% | Reduced lipase activity |
| c.256G>A (p.Gly86Arg) | Missense | 0.005% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations such as p.Thr34Met and p.Gly86Arg reduce or abolish lipase activity, impairing triglyceride hydrolysis.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • lipase activity | • triglyceride lipase activity |
| • lipid metabolic process | • extracellular region |
Pathways
• Triglyceride metabolism
• Lipoprotein metabolism
Protein Summary
The LIPM protein is a 399-amino acid lipase that catalyzes the hydrolysis of triglycerides. It contains a conserved catalytic triad (Ser-Asp-His) typical of serine lipases. The protein is secreted and may function in extracellular lipid metabolism. UniProt ID: Q5VXJ0.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LIPM Knockout HEK293 Cell Line | EDJ-KQ14085 | Human | 340654 | Details Get a Quote |
| LIPM Knockout HeLa Cell Line | EDJ-KQ59692 | Human | 340654 | Details Get a Quote |
| LIPM Knockout A-549 Cell Line | EDJ-KQ68163 | Human | 340654 | Details Get a Quote |
| LIPM Knockout HCT 116 Cell Line | EDJ-KQ76539 | Human | 340654 | Details Get a Quote |
