LINGO1
Leucine Rich Repeat And Ig Domain Containing 1
Gene Information Card
| Symbol | LINGO1 |
|---|---|
| Full Name | Leucine Rich Repeat And Ig Domain Containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q24.3 |
| NCBI Gene ID | 84894 ncbi.nlm.nih.gov/gene/84894 |
| Ensembl ID | ENSG00000169783 |
| UniProt ID | Q96FE5 |
| OMIM ID | 609791 |
| HGNC ID | 21205 |
| Aliases | LERN1, LRRN6, UNQ201, FLJ44965 |
Description
LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a protein-coding gene that encodes a transmembrane protein predominantly expressed in the central nervous system. It functions as a negative regulator of neuronal survival, axon regeneration, and oligodendrocyte differentiation. LINGO1 is a component of the Nogo receptor complex and inhibits neurite outgrowth and myelination. Variants in LINGO1 have been associated with essential tremor and multiple sclerosis susceptibility.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Essential Tremor | Genetic association; specific mechanism unclear | OMIM 609791; GWAS studies |
| Multiple Sclerosis | LINGO1 variants may influence disease susceptibility and progression | ClinVar; NCBI Gene |
| Parkinson's Disease | Potential genetic risk factor | NCBI Gene; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal Cord | 8.2 | Medium |
| Testis | 1.3 | Low |
| Heart | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.0 | Neuroblastoma cell line |
| U-87 MG | 10.2 | Glioblastoma cell line |
| HEK 293 | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs9652490 | SNP | 0.3 (allele frequency) | Associated with essential tremor risk |
| rs11856808 | SNP | 0.2 | Potential modifier in multiple sclerosis |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; LINGO1 knockout in mice shows enhanced myelination and axon regeneration.
Gain of Function (GOF)
Overexpression of LINGO1 inhibits oligodendrocyte differentiation and myelination.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • negative regulation of axon regeneration | • negative regulation of oligodendrocyte differentiation |
| • negative regulation of myelination | • protein binding |
| • transmembrane signaling receptor activity |
Pathways
• Nogo receptor signaling
• Axon guidance
• Myelination signaling
Protein Summary
LINGO1 is a 620-amino acid transmembrane protein containing leucine-rich repeats and an immunoglobulin-like domain. It is expressed on neurons and oligodendrocytes, where it interacts with the Nogo-66 receptor (NgR1) and p75/TROY to inhibit neurite outgrowth and myelination. LINGO1 is a key target for therapeutic intervention in demyelinating diseases and spinal cord injury.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LINGO1 Knockout HEK293 Cell Line | EDJ-KQ10242 | Human | 84894 | Details Get a Quote |
| LINGO1 Knockout A-549 Cell Line | EDJ-KQ37433 | Human | 84894 | Details Get a Quote |
| LINGO1 Knockout HCT 116 Cell Line | EDJ-KQ37434 | Human | 84894 | Details Get a Quote |
| LINGO1 Knockout HeLa Cell Line | EDJ-KQ57678 | Human | 84894 | Details Get a Quote |
