LIN28B Gene - RNA-Binding Protein Regulating Development and Cancer
Comprehensive biomedical resource for LIN28B: genomic data, expression, mutations, and disease associations
Gene Information Card
| Symbol | LIN28B |
|---|---|
| Full Name | lin-28 homolog B |
| Gene Type | protein-coding |
| Chromosomal Location | 6q21 |
| NCBI Gene ID | 389421 ncbi.nlm.nih.gov/gene/389421 |
| Ensembl ID | ENSG00000187772 |
| UniProt ID | Q6ZN17 |
| OMIM ID | 611044 |
| HGNC ID | 32207 |
| Aliases | CSDD2, LIN-28B, MIRLET7B, let-7, lin-28B |
Description
LIN28B encodes a RNA-binding protein that inhibits the maturation of let-7 family microRNAs, thereby promoting stem cell self-renewal and proliferation. It is involved in developmental timing, glucose metabolism, and is frequently overexpressed in various cancers, contributing to poor prognosis and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | LIN28B overexpression suppresses let-7, leading to de-repression of oncogenes (e.g., HMGA2, MYC) and enhanced proliferation | PMID: 21499247 |
| Colorectal cancer | LIN28B amplification and overexpression correlate with advanced stage and poor survival via let-7 downregulation | PMID: 21746835 |
| Ovarian cancer | LIN28B upregulation promotes tumorigenesis and chemoresistance through let-7 inhibition | PMID: 22949634 |
| Wilms tumor | LIN28B overexpression is associated with aggressive histology and relapse | PMID: 25261932 |
| Type 2 diabetes | LIN28B variants influence insulin sensitivity and glucose homeostasis via let-7 regulation | PMID: 25985138 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Placenta | 8.3 | Medium |
| Liver | 2.1 | Low |
| Kidney | 1.8 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 3.2 | Hepatocellular carcinoma cell line |
| HeLa | 2.8 | Cervical adenocarcinoma cell line |
| A549 | 1.5 | Lung carcinoma cell line |
| MCF7 | 0.9 | Breast adenocarcinoma cell line |
| K562 | 0.4 | Chronic myelogenous leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; likely loss of function |
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown significance |
| c.500G>A (p.Arg167Gln) | Missense | <0.01% | Unknown significance |
| Amplification | Copy number gain | ~5% in ovarian cancer | Gain of function; increased LIN28B expression |
Mutation functional classification
Loss of Function (LOF)
Rare truncating or start-loss variants (e.g., p.Met1?) are predicted to abolish protein function.
Gain of Function (GOF)
Gene amplification and overexpression in multiple cancers lead to increased suppression of let-7 and oncogenic activation.
Dominant Negative (DN)
No dominant-negative mutations have been reported for LIN28B.
View complete mutation data：
Gene Ontology (GO)
Pathways
• let-7 inhibition of oncogenes (HMGA2
• MYC
• RAS)
• LIN28/let-7 pathway in stem cell differentiation
• PI3K/AKT signaling (via let-7 targets)
• p53 pathway (via let-7 regulation of CDKN1A)
Protein Summary
LIN28B is a 250-amino acid RNA-binding protein containing a cold-shock domain and two CCHC zinc finger motifs. It binds to the terminal loop of let-7 precursor microRNAs, blocking their processing by DICER and DROSHA. This leads to reduced mature let-7 levels, allowing expression of oncogenic targets such as HMGA2, MYC, and RAS. LIN28B also modulates mRNA translation and stability independently of let-7. Its expression is high in embryonic stem cells and certain cancers, where it promotes self-renewal, proliferation, and metabolic reprogramming.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LIN28B Knockout HEK293 Cell Line | EDJ-KQ3645 | Human | 389421 | Details Get a Quote |
| LIN28B Knockout A-549 Cell Line | EDJ-KQ25606 | Human | 389421 | Details Get a Quote |
| LIN28B Knockout HeLa Cell Line | EDJ-KQ60086 | Human | 389421 | Details Get a Quote |
| LIN28B Knockout HCT 116 Cell Line | EDJ-KQ76925 | Human | 389421 | Details Get a Quote |
