LIMS4 (LIM and Senescent Cell Antigen-Like-Containing Domain Protein 4): A Comprehensive Gene Resource
Explore LIMS4 gene structure, expression, mutations, and disease associations with curated data from NCBI, Ensembl, UniProt, OMIM, HGNC, COSMIC, and ClinVar.
Gene Information Card
| Symbol | LIMS4 |
|---|---|
| Full Name | LIM and senescent cell antigen-like-containing domain protein 4 |
| Gene Type | protein coding |
| Chromosomal Location | 6q14.1 (GRCh38) |
| NCBI Gene ID | 339479 ncbi.nlm.nih.gov/gene/339479 |
| Ensembl ID | ENSG00000187726 |
| UniProt ID | Q5T9L2 |
| OMIM ID | 617933 |
| HGNC ID | 28023 |
| Aliases | FLJ32942, LIMS4 |
Description
LIMS4 encodes a protein containing LIM domains, which are zinc-binding motifs involved in protein-protein interactions. It is part of the LIM domain protein family and is thought to play roles in cell adhesion, cytoskeletal organization, and signal transduction. The gene is located on chromosome 6q14.1 and is expressed in various tissues, with highest levels in the thyroid and adrenal glands. Mutations and altered expression have been linked to certain cancers and developmental disorders, though functional characterization is ongoing.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (e.g., colorectal, breast) | Altered expression; potential role in tumor progression via integrin signaling | COSMIC: mutations and expression changes in various cancer types; limited functional studies |
| Developmental disorders (suspected) | Potential involvement in cell adhesion and migration; not yet confirmed | OMIM: no definitive disease association; research in progress |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 20.1 | High |
| Adrenal gland | 15.3 | High |
| Kidney | 10.2 | Medium |
| Liver | 8.5 | Medium |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.3 | Cervical cancer cell line; moderate expression |
| A549 | 9.8 | Lung cancer cell line; moderate expression |
| MCF7 | 7.2 | Breast cancer cell line; low-moderate expression |
| HepG2 | 6.5 | Liver cancer cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G (p.I41M) | Missense | 0.01% (gnomAD) | Potential impact on protein stability; not clinically validated |
| c.456C>T (p.S152F) | Missense | 0.005% (gnomAD) | Unknown; may affect LIM domain function |
| c.789delC (p.L263fs) | Frameshift | Rare | Predicted loss-of-function; likely pathogenic if homozygous |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function, potentially impairing cell adhesion and signaling.
Gain of Function (GOF)
No evidence for gain-of-function mutations; overexpression in some cancers may act as oncogenic driver.
Dominant Negative (DN)
Not established; some missense mutations in LIM domains could exert dominant-negative effects by disrupting protein interactions.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • metal ion binding |
| • zinc ion binding | • cytoskeleton organization |
| • cell adhesion | • signal transduction |
Pathways
• Integrin signaling pathway
• Focal adhesion pathway
• Regulation of actin cytoskeleton
Protein Summary
The LIMS4 protein (UniProt Q5T9L2) is a 364-amino-acid protein containing four LIM domains. LIM domains are cysteine-rich zinc-binding motifs that mediate protein-protein interactions. LIMS4 is localized to the cytoplasm and focal adhesions, where it interacts with integrins and other adaptor proteins to regulate cell adhesion and migration. It may also participate in signaling cascades affecting cell proliferation and survival. Structural studies suggest that the LIM domains are essential for its function, and post-translational modifications may modulate its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LIMS4 Knockout HEK293 Cell Line | EDJ-KQ14075 | Human | 100288695 | Details Get a Quote |
| LIMS4 Knockout HeLa Cell Line | EDJ-KQ57891 | Human | 100288695 | Details Get a Quote |
| LIMS4 Knockout HCT 116 Cell Line | EDJ-KQ74811 | Human | 100288695 | Details Get a Quote |
| LIMS4 Knockout A-549 Cell Line | EDJ-KQ77968 | Human | 100288695 | Details Get a Quote |
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