LIMS3: LIM Zinc Finger Domain Containing 3
A scaffold protein involved in integrin-mediated signaling and cytoskeletal organization
Gene Information Card
| Symbol | LIMS3 |
|---|---|
| Full Name | LIM zinc finger domain containing 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 96626 ncbi.nlm.nih.gov/gene/96626 |
| Ensembl ID | ENSG00000162931 |
| UniProt ID | Q5JY77 |
| OMIM ID | 617911 |
| HGNC ID | 25137 |
| Aliases | PINCH3, LIM domain-containing protein 3 |
Description
LIMS3 (LIM zinc finger domain containing 3), also known as PINCH3, encodes a protein containing LIM domains that function as scaffolds in integrin-mediated signaling and cytoskeletal organization. It is involved in cell adhesion, migration, and survival pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Adipose tissue | 6.1 | Low |
| Brain | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.7 | Moderate expression |
| HeLa | 6.2 | Low expression |
| K562 | 4.1 | Low expression |
| A549 | 3.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • cytoplasm (GO:0005737) | • focal adhesion (GO:0005925) |
Pathways
• Integrin signaling pathway (Reactome: R-HSA-354192)
• Cell-extracellular matrix interactions (Reactome: R-HSA-446353)
Protein Summary
The LIMS3 protein contains LIM domains that mediate protein-protein interactions, acting as a scaffold in focal adhesions. It is involved in integrin signaling and cytoskeletal dynamics, with highest expression in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LIMS3 Knockout HEK293 Cell Line | EDJ-KQ10719 | Human | 96626 | Details Get a Quote |
| LIMS3 Knockout HCT 116 Cell Line | EDJ-KQ39609 | Human | 96626 | Details Get a Quote |
| LIMS3 Knockout HeLa Cell Line | EDJ-KQ39610 | Human | 96626 | Details Get a Quote |
| LIMS3 Knockout A-549 Cell Line | EDJ-KQ78016 | Human | 96626 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
