LIF Gene - Leukemia Inhibitory Factor
A pleiotropic cytokine involved in development, inflammation, and cancer
Gene Information Card
| Symbol | LIF |
|---|---|
| Full Name | Leukemia Inhibitory Factor |
| Gene Type | protein-coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 3976 ncbi.nlm.nih.gov/gene/3976 |
| Ensembl ID | ENSG00000128342 |
| UniProt ID | P15018 |
| OMIM ID | 159540 |
| HGNC ID | 6596 |
| Aliases | CDF, DIA, HILDA, MLPLI |
Description
The LIF gene encodes leukemia inhibitory factor, a pleiotropic cytokine of the interleukin-6 family. It regulates cell growth, differentiation, and survival in various tissues, including embryonic stem cells, hematopoietic cells, and neurons. LIF is involved in implantation, inflammation, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | LIF promotes tumor growth and metastasis via JAK/STAT3 signaling | COSMIC, ClinVar |
| Infertility | LIF deficiency impairs embryo implantation | OMIM, NCBI |
| Inflammatory disorders | LIF modulates immune responses and cytokine production | UniProt, NCBI |
| Neurological diseases | LIF supports neuronal survival and regeneration | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 0.8 | Low |
| Endometrium | 12.5 | Medium |
| Placenta | 45.2 | High |
| Testis | 3.1 | Low |
| Brain (cerebellum) | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 0.5 | Low expression |
| HeLa (cervical cancer) | 8.3 | Medium expression |
| HepG2 (liver cancer) | 2.1 | Low expression |
| MCF7 (breast cancer) | 15.6 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.340C>T | missense | <0.01% | Unknown |
| c.500G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• JAK-STAT signaling pathway (KEGG: hsa04630)
• IL-6 family signaling (Reactome: R-HSA-447115)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Embryo implantation (Reactome: R-HSA-375276)
Protein Summary
Leukemia inhibitory factor (LIF) is a secreted glycoprotein of 202 amino acids (UniProt P15018). It binds to the LIF receptor (LIFR) and gp130, activating JAK/STAT3 and MAPK pathways. LIF maintains embryonic stem cell pluripotency, regulates hematopoietic differentiation, and modulates inflammatory responses. Overexpression is linked to several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LIF Knockout HEK293 Cell Line | EDJ-KQ508 | Human | 3976 | Details Get a Quote |
| LIFR Knockout HEK293 Cell Line | EDJ-KQ509 | Human | 3977 | Details Get a Quote |
| CBLIF Knockout HEK293 Cell Line | EDJ-KQ4711 | Human | 2694 | Details Get a Quote |
| LIFR Knockout A-549 Cell Line | EDJ-KQ18012 | Human | 3977 | Details Get a Quote |
| LIF Knockout A-549 Cell Line | EDJ-KQ18831 | Human | 3976 | Details Get a Quote |
| LIF Knockout HCT 116 Cell Line | EDJ-KQ18832 | Human | 3976 | Details Get a Quote |
| LIF Knockout HeLa Cell Line | EDJ-KQ18833 | Human | 3976 | Details Get a Quote |
| LIFR Knockout HCT 116 Cell Line | EDC11225 | Human | 3977 | Details Get a Quote |
| LIFR Knockout HeLa Cell Line | EDJ-KQ18836 | Human | 3977 | Details Get a Quote |
| LIFR Knockout NCI-H1299 Cell Line | EDJ-KZ332 | Human | 3977 | Details Get a Quote |
| CBLIF Knockout HeLa Cell Line | EDJ-KQ53341 | Human | 2694 | Details Get a Quote |
| CBLIF Knockout A-549 Cell Line | EDJ-KQ61821 | Human | 2694 | Details Get a Quote |
| CBLIF Knockout HCT 116 Cell Line | EDJ-KQ70308 | Human | 2694 | Details Get a Quote |
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