LGALS9C
Galectin 9C
Gene Information Card
| Symbol | LGALS9C |
|---|---|
| Full Name | Galectin 9C |
| Gene Type | Protein coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 654346 ncbi.nlm.nih.gov/gene/654346 |
| Ensembl ID | ENSG00000214548 |
| UniProt ID | A6NNN2 |
| OMIM ID | Not available |
| HGNC ID | HGNC:33913 |
| Aliases | Galectin-9C, galectin 9C, lectin galactoside-binding soluble 9C |
Description
LGALS9C (galectin 9C) is a protein-coding gene belonging to the galectin family of beta-galactoside-binding lectins. It is located on chromosome 17q11.2 and encodes a protein involved in immune modulation, cell adhesion, and apoptosis. The gene is closely related to LGALS9 (galectin-9) but is a distinct paralog. Expression is detected in various tissues, particularly in immune cells and epithelial tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered galectin-9C expression may modulate tumor immune evasion and apoptosis | Limited evidence; inferred from galectin family studies |
| Inflammatory diseases | Potential role in T-cell regulation and cytokine modulation | Indirect evidence from galectin-9 studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Lung | 6.4 | Low |
| Small intestine | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Moderate expression |
| HeLa | 9.7 | Low expression |
| K562 | 7.4 | Low expression |
| MCF7 | 5.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in LGALS9C.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in LGALS9C.
Dominant Negative (DN)
No dominant-negative mutations reported for LGALS9C.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • protein homodimerization activity |
| • extracellular exosome | • apoptotic process |
| • cell adhesion |
Pathways
• Galectin pathway
• Apoptosis signaling
Protein Summary
Galectin-9C is a beta-galactoside-binding lectin that shares structural similarity with galectin-9. It contains a carbohydrate recognition domain (CRD) and is involved in cell-cell interactions, immune regulation, and apoptosis. The protein is secreted and can modulate T-cell responses. Its exact physiological role remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS9C Knockout HEK293 Cell Line | EDJ-KQ2160 | Human | 654346 | Details Get a Quote |
| LGALS9C Knockout HeLa Cell Line | EDJ-KQ60667 | Human | 654346 | Details Get a Quote |
| LGALS9C Knockout A-549 Cell Line | EDJ-KQ69141 | Human | 654346 | Details Get a Quote |
| LGALS9C Knockout HCT 116 Cell Line | EDJ-KQ77493 | Human | 654346 | Details Get a Quote |
