LGALS9B
Galectin 9B: A Tandem-Repeat Galectin Involved in Immune Modulation and Cancer Biology
Gene Information Card
| Symbol | LGALS9B |
|---|---|
| Full Name | Galectin 9B |
| Gene Type | Protein coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 284194 ncbi.nlm.nih.gov/gene/284194 |
| Ensembl ID | ENSG00000170266 |
| UniProt ID | Q6DKJ4 |
| OMIM ID | None |
| HGNC ID | 24885 |
| Aliases | Galectin-9B, Gal-9B, LGALS9, galectin-9 |
Description
LGALS9B (galectin 9B) is a protein-coding gene located on chromosome 17q11.2. It encodes a member of the galectin family of beta-galactoside-binding proteins. Galectin 9B contains two carbohydrate recognition domains (CRDs) and is involved in modulating immune responses, cell adhesion, and apoptosis. The gene is closely related to LGALS9 (galectin 9) and is thought to arise from a gene duplication event. LGALS9B expression is detected in various tissues and is implicated in cancer progression and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered galectin-9B expression may modulate tumor immune evasion and metastasis through binding to glycans on immune cells. | COSMIC; literature |
| Inflammatory diseases | Galectin-9B can induce T-cell apoptosis and regulate cytokine production, contributing to inflammation. | Literature; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 10.2 | Medium |
| Lymph node | 8.5 | Medium |
| Bone marrow | 6.3 | Low |
| Lung | 4.1 | Low |
| Liver | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | High expression in recombinant systems |
| Jurkat | 7.5 | Moderate expression |
| HeLa | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | <0.01% | Unknown functional effect |
| c.456G>A (p.Trp152*) | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Trp152*) likely lead to truncated protein and loss of carbohydrate-binding activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • protein homodimerization activity |
| • extracellular space | • apoptotic process |
| • immune response |
Pathways
• Galectin pathway
• Apoptosis signaling
• T-cell receptor signaling
Protein Summary
Galectin-9B is a 36 kDa protein with two carbohydrate recognition domains (CRDs) connected by a linker peptide. It binds beta-galactoside sugars on cell surface glycoproteins and can induce apoptosis in T-cells, modulate cell adhesion, and regulate immune responses. The protein is secreted and can act as a cytokine-like factor. Its expression is upregulated in certain cancers and inflammatory conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS9B Knockout HEK293 Cell Line | EDJ-KQ14059 | Human | 284194 | Details Get a Quote |
| LGALS9B Knockout HeLa Cell Line | EDJ-KQ59441 | Human | 284194 | Details Get a Quote |
| LGALS9B Knockout A-549 Cell Line | EDJ-KQ67904 | Human | 284194 | Details Get a Quote |
| LGALS9B Knockout HCT 116 Cell Line | EDJ-KQ76284 | Human | 284194 | Details Get a Quote |
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