LGALS8 (Galectin 8)
A tandem-repeat galectin involved in cell adhesion, immune modulation, and autophagy regulation
Gene Information Card
| Symbol | LGALS8 |
|---|---|
| Full Name | Galectin 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q43 |
| NCBI Gene ID | 3964 ncbi.nlm.nih.gov/gene/3964 |
| Ensembl ID | ENSG00000116977 |
| UniProt ID | O00214 |
| OMIM ID | 606099 |
| HGNC ID | 6568 |
| Aliases | Gal-8, PCTA-1, Po66-CBP |
Description
LGALS8 encodes galectin-8, a member of the galectin family of beta-galactoside-binding proteins. Galectin-8 contains two carbohydrate recognition domains (CRDs) connected by a linker peptide. It functions in cell adhesion, migration, immune modulation, autophagy, and endocytosis. LGALS8 is widely expressed and its dysregulation is implicated in cancer, autoimmune diseases, and infectious diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression of galectin-8 modulates tumor cell adhesion, migration, and immune evasion | PMID: 25687249; PMID: 29127120 |
| Rheumatoid arthritis | Galectin-8 promotes inflammatory cytokine production and osteoclastogenesis | PMID: 28336555 |
| Systemic lupus erythematosus | Galectin-8 levels correlate with disease activity and autoantibody production | PMID: 29562367 |
| Infectious diseases (e.g., Salmonella, HIV) | Galectin-8 restricts bacterial and viral infection by targeting pathogen-containing vacuoles to autophagy | PMID: 22980980; PMID: 26068852 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 7.1 | Low |
| Heart | 5.9 | Low |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Cervical cancer cell line |
| A549 | 11.5 | Lung adenocarcinoma cell line |
| HepG2 | 9.8 | Hepatocellular carcinoma cell line |
| MCF7 | 7.3 | Breast cancer cell line |
| Jurkat | 6.1 | T-cell leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.442G>A (p.Gly148Arg) | Missense | <0.01% | Altered carbohydrate binding; potential impact on function |
| c.625C>T (p.Arg209Trp) | Missense | <0.01% | Located in CRD2; functional significance unknown |
| c.1030G>A (p.Glu344Lys) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in LGALS8.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in LGALS8.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported in LGALS8.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Galectin-8 in autophagy (R-HSA-9616222)
• Galectin-8 in immune regulation (R-HSA-5621481)
• Galectin-8 in cell adhesion (R-HSA-202733)
Protein Summary
Galectin-8 is a 359-amino acid protein with two CRDs (N-terminal and C-terminal) connected by a linker. It exists as a homodimer and binds beta-galactoside sugars on cell surface glycoproteins. Galectin-8 modulates cell adhesion by interacting with integrins, regulates autophagy by recognizing damaged endosomes, and influences immune responses by activating dendritic cells and T cells. Its expression is altered in various cancers and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS8 Knockout HEK293 Cell Line | EDJ-KQ3067 | Human | 3964 | Details Get a Quote |
| LGALS8 Knockout A-549 Cell Line | EDJ-KQ22959 | Human | 3964 | Details Get a Quote |
| LGALS8 Knockout HCT 116 Cell Line | EDJ-KQ24337 | Human | 3964 | Details Get a Quote |
| LGALS8 Knockout HeLa Cell Line | EDJ-KQ24338 | Human | 3964 | Details Get a Quote |
| Lgals8 Knockout RAW 264.7 Cell Line | EDJ-KZ330 | Mouse | 56048 | Details Get a Quote |
| LGALS8 Overexpression HeLa Stable Cell Line | EDJ-GQ115 | Human | 3964 | Details Get a Quote |
| Lgals8 Overexpression U2OS-Cas9 Stable Cell Line | EDC90345 | Mouse | 56048 | Details Get a Quote |
