LGALS3BP
Galectin-3 Binding Protein: A Multifunctional Glycoprotein in Cancer and Immune Modulation
Gene Information Card
| Symbol | LGALS3BP |
|---|---|
| Full Name | Galectin-3 Binding Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 3959 ncbi.nlm.nih.gov/gene/3959 |
| Ensembl ID | ENSG00000108679 |
| UniProt ID | Q08380 |
| OMIM ID | 600626 |
| HGNC ID | 6569 |
| Aliases | 90K, MAC-2 BP, BTBD17F, M2BP |
Description
LGALS3BP encodes a secreted glycoprotein that binds galectin-3, laminin, and other extracellular matrix components. It is involved in cell adhesion, immune modulation, and tumor progression. Elevated levels are associated with various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (breast, lung, colorectal, melanoma) | Overexpression promotes tumor growth and metastasis via galectin-3 interaction and immune evasion | Multiple studies in NCBI PubMed |
| HIV infection | Increased serum levels correlate with disease progression and immune activation | ClinVar, NCBI |
| Hepatocellular carcinoma | Upregulation linked to poor prognosis and fibrosis | COSMIC, NCBI |
| Systemic sclerosis | Elevated levels associated with fibrosis and autoimmunity | OMIM, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Breast | 15.2 | Medium |
| Colon | 10.1 | Medium |
| Spleen | 6.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 18.4 | High expression |
| MCF7 (breast cancer) | 22.1 | High expression |
| HepG2 (liver cancer) | 14.7 | Medium expression |
| HeLa (cervical cancer) | 11.3 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.1456C>T (p.Arg486Trp) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.789_790insA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.789_790insA) likely lead to truncated protein and loss of galectin-3 binding.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • protein binding |
| • cell adhesion | • immune response |
| • receptor-mediated endocytosis |
Pathways
• Galectin-3 pathway
• Extracellular matrix organization
• Integrin signaling
Protein Summary
LGALS3BP encodes a 90 kDa secreted glycoprotein (also known as 90K or MAC-2 BP) that binds galectin-3 and laminin. It modulates cell adhesion, immune surveillance, and tumor progression. The protein is heavily glycosylated and exists as a multimer. Elevated serum levels are a biomarker in cancer and HIV.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS3BP Knockout HEK293 Cell Line | EDJ-KQ2621 | Human | 3959 | Details Get a Quote |
| LGALS3BP Knockout A-549 Cell Line | EDJ-KQ23351 | Human | 3959 | Details Get a Quote |
| LGALS3BP Knockout HCT 116 Cell Line | EDJ-KQ23352 | Human | 3959 | Details Get a Quote |
| LGALS3BP Knockout HeLa Cell Line | EDJ-KQ23353 | Human | 3959 | Details Get a Quote |
