LGALS16: Galectin 16
A member of the galectin family with potential roles in immune regulation and cancer
Gene Information Card
| Symbol | LGALS16 |
|---|---|
| Full Name | Galectin 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | Q8N6G6 |
| OMIM ID | 615709 |
| HGNC ID | 24852 |
| Aliases | Gal-16, GAL16 |
Description
LGALS16 (galectin 16) is a protein-coding gene belonging to the galectin family of beta-galactoside-binding proteins. Galectins are involved in modulating cell-cell and cell-matrix interactions, immune responses, and apoptosis. LGALS16 is specifically expressed in certain tissues and has been implicated in immune regulation and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Potential role in tumor immune evasion and metastasis through modulation of immune cell interactions | Limited evidence from expression studies and in vitro assays; not yet validated in large cohorts |
| Autoimmune disorders | Possible involvement in T-cell regulation and inflammatory responses | Hypothetical based on galectin family functions; no direct evidence for LGALS16 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 0.3 | Low |
| Testis | 0.1 | Low |
| Lung | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • carbohydrate binding (GO:0030246) |
| • extracellular region (GO:0005576) |
Pathways
• Galectin pathway (Reactome: R-HSA-198933)
Protein Summary
Galectin 16 is a 16 kDa protein containing a single carbohydrate recognition domain (CRD) characteristic of prototype galectins. It binds beta-galactoside sugars and may modulate immune cell adhesion and signaling. Its expression is restricted, and its physiological functions remain poorly characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS16 Knockout HEK293 Cell Line | EDJ-KQ10707 | Human | 148003 | Details Get a Quote |
| LGALS16 Knockout HeLa Cell Line | EDJ-KQ58595 | Human | 148003 | Details Get a Quote |
| LGALS16 Knockout A-549 Cell Line | EDJ-KQ67079 | Human | 148003 | Details Get a Quote |
| LGALS16 Knockout HCT 116 Cell Line | EDJ-KQ75486 | Human | 148003 | Details Get a Quote |
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