LGALS14 (Galectin-14)
A member of the galectin family with roles in immune regulation and placental development
Gene Information Card
| Symbol | LGALS14 |
|---|---|
| Full Name | Galectin-14 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 56891 ncbi.nlm.nih.gov/gene/56891 |
| Ensembl ID | ENSG00000105669 |
| UniProt ID | Q8TCE9 |
| OMIM ID | 608626 |
| HGNC ID | HGNC:6566 |
| Aliases | GAL14, PLAC8, galectin-14 |
Description
LGALS14 encodes galectin-14, a member of the galectin family of beta-galactoside-binding proteins. It is predominantly expressed in the placenta and plays a role in immune modulation, particularly at the maternal-fetal interface. The protein is involved in cell adhesion, apoptosis, and regulation of inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Preterm birth | Altered placental expression may disrupt immune tolerance | PMID: 21536867 |
| Preeclampsia | Dysregulation of galectin-14 in placental tissue | PMID: 23103650 |
| Endometriosis | Reduced expression in eutopic endometrium | PMID: 24603458 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | High |
| Uterus | 0.8 | Low |
| Lung | 0.2 | Not detected |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| JEG-3 (choriocarcinoma) | 15.2 | Placental origin |
| BeWo (choriocarcinoma) | 10.8 | Placental origin |
| HeLa | 0.3 | Cervical cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon |
| c.202C>T (p.Arg68Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • sugar binding (GO:0005529) | • carbohydrate binding (GO:0030246) |
| • cell adhesion (GO:0007155) | • apoptotic process (GO:0006915) |
| • innate immune response (GO:0045087) |
Pathways
• Galectin pathway (Reactome: R-HSA-5621481)
• Immune system (Reactome: R-HSA-168256)
Protein Summary
Galectin-14 is a 14 kDa soluble protein containing a single carbohydrate recognition domain (CRD) that binds beta-galactoside sugars. It is secreted and localizes to the extracellular matrix and cell surface. In the placenta, it modulates T-cell responses and promotes maternal-fetal tolerance. Its expression is largely restricted to placental trophoblasts.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS14 Knockout HEK293 Cell Line | EDJ-KQ14060 | Human | 56891 | Details Get a Quote |
| LGALS14 Knockout HeLa Cell Line | EDJ-KQ56760 | Human | 56891 | Details Get a Quote |
| LGALS14 Knockout A-549 Cell Line | EDJ-KQ65265 | Human | 56891 | Details Get a Quote |
| LGALS14 Knockout HCT 116 Cell Line | EDJ-KQ73706 | Human | 56891 | Details Get a Quote |
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