LGALS12: Galectin-12 Gene
A member of the galectin family involved in adipocyte biology and apoptosis
Gene Information Card
| Symbol | LGALS12 |
|---|---|
| Full Name | Galectin 12 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 85329 ncbi.nlm.nih.gov/gene/85329 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q96DT0 |
| OMIM ID | 608211 |
| HGNC ID | 15713 |
| Aliases | GAL12, GRIP1 |
Description
LGALS12 encodes galectin-12, a member of the galectin family of beta-galactoside-binding proteins. It is predominantly expressed in adipose tissue and plays a role in adipocyte differentiation, lipid metabolism, and apoptosis. Galectin-12 localizes to the cytoplasm and nucleus and may regulate cell cycle and immune responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered expression in adipose tissue may affect adipocyte function and energy homeostasis. | NCBI Gene, UniProt |
| Type 2 Diabetes | Potential involvement in insulin resistance through adipokine regulation. | NCBI Gene |
| Cancer | Dysregulated expression reported in certain cancers; may influence apoptosis and cell proliferation. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Lung | 2.1 | Low |
| Spleen | 1.8 | Low |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| 3T3-L1 (adipocyte) | 15.3 | Differentiated adipocytes |
| HeLa | 0.5 | Low expression |
| HEK293 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.331C>T (p.Arg111Cys) | Missense | <0.1% | Unknown functional impact |
| c.487G>A (p.Gly163Ser) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • mannose binding (GO:0005537) | • carbohydrate binding (GO:0030246) |
| • apoptotic process (GO:0006915) | • protein homodimerization activity (GO:0042803) |
| • nucleus (GO:0005634) |
Pathways
• Galectin pathway (Reactome: R-HSA-198933)
• Apoptosis (KEGG: hsa04210)
Protein Summary
Galectin-12 is a 336-amino acid protein with two carbohydrate recognition domains (CRDs). It binds beta-galactoside sugars and is involved in adipocyte differentiation, apoptosis, and immune modulation. The protein is primarily cytoplasmic but can translocate to the nucleus. It is encoded by the LGALS12 gene on chromosome 11q13.1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LGALS12 Knockout HEK293 Cell Line | EDJ-KQ10340 | Human | 85329 | Details Get a Quote |
| LGALS12 Knockout HeLa Cell Line | EDJ-KQ57703 | Human | 85329 | Details Get a Quote |
| LGALS12 Knockout A-549 Cell Line | EDJ-KQ66205 | Human | 85329 | Details Get a Quote |
| LGALS12 Knockout HCT 116 Cell Line | EDJ-KQ74631 | Human | 85329 | Details Get a Quote |
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