LCP1 (Lymphocyte Cytosolic Protein 1)
Actin-binding protein L-plastin: roles in immune cell function and cancer
Gene Information Card
| Symbol | LCP1 |
|---|---|
| Full Name | Lymphocyte Cytosolic Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.13 |
| NCBI Gene ID | 3936 ncbi.nlm.nih.gov/gene/3936 |
| Ensembl ID | ENSG00000136167 |
| UniProt ID | P13796 |
| OMIM ID | 153432 |
| HGNC ID | 6528 |
| Aliases | LPL, PLS2, L-plastin |
Description
LCP1 encodes L-plastin, a member of the actin-binding plastin/fimbrin family. L-plastin is primarily expressed in hematopoietic cells and is involved in cytoskeletal reorganization, cell adhesion, migration, and immune synapse formation. It contains two EF-hand calcium-binding domains and two actin-binding domains. Phosphorylation by PKC and other kinases regulates its activity. Overexpression and mutations are linked to various cancers and immune disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | LCP1 overexpression promotes cell migration and invasion via actin cytoskeleton remodeling | PMID: 23541953 |
| Breast cancer | Elevated L-plastin correlates with metastasis and poor prognosis | PMID: 20574929 |
| Chronic lymphocytic leukemia (CLL) | LCP1 mutations (e.g., D473N) associated with disease progression | PMID: 25686833 |
| Autoimmune lymphoproliferative syndrome | Rare LCP1 variants impair actin dynamics in T cells | PMID: 29276052 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 45.2 | High |
| Lymph node | 38.7 | High |
| Bone marrow | 32.1 | High |
| Whole blood | 28.5 | High |
| Lung | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 62.4 | Myelogenous leukemia line |
| Raji (Burkitt lymphoma) | 55.8 | B-cell line |
| Jurkat (T-cell leukemia) | 48.2 | T-cell line |
| HeLa (cervical cancer) | 12.1 | Epithelial line, lower expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| D473N | Missense | <1% | Alters actin-binding affinity; associated with CLL |
| A398T | Missense | <0.5% | Reported in autoimmune lymphoproliferative syndrome |
| R572W | Missense | <0.1% | Potential loss of function; rare population variant |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., R572W) reduce actin-bundling activity, impairing immune cell migration.
Gain of Function (GOF)
Overexpression and phosphorylation (e.g., at Ser5) enhance cell motility and invasion in cancers.
Dominant Negative (DN)
Not well documented; some mutations may interfere with wild-type L-plastin dimerization.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • calcium ion binding |
| • actin filament bundle assembly | • cell migration |
| • immune response | • cytoskeleton organization |
Pathways
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Fc gamma R-mediated phagocytosis (KEGG: hsa04666)
• Chemokine signaling pathway (KEGG: hsa04062)
Protein Summary
L-plastin (LCP1) is a 627-amino acid actin-bundling protein with two EF-hand domains and two actin-binding domains. It is highly expressed in hematopoietic cells and regulates cytoskeletal dynamics essential for immune cell adhesion, migration, and phagocytosis. Phosphorylation at Ser5 by PKC enhances its actin-bundling activity. In cancer, LCP1 overexpression promotes metastasis, while mutations in immune disorders impair T-cell function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LCP1 Knockout HEK293 Cell Line | EDJ-KQ5112 | Human | 3936 | Details Get a Quote |
| LCP1 Knockout HCT 116 Cell Line | EDJ-KQ28062 | Human | 3936 | Details Get a Quote |
| LCP1 Knockout HeLa Cell Line | EDJ-KQ53782 | Human | 3936 | Details Get a Quote |
| LCP1 Knockout A-549 Cell Line | EDJ-KQ62260 | Human | 3936 | Details Get a Quote |
