LCOR Gene (Ligand Dependent Co-repressor)
Comprehensive genomic and functional overview of LCOR, a transcriptional co-regulator involved in nuclear receptor signaling and cancer.
Gene Information Card
| Symbol | LCOR |
|---|---|
| Full Name | Ligand Dependent Co-repressor |
| Gene Type | Protein coding |
| Chromosomal Location | 10q24.1 |
| NCBI Gene ID | 84458 ncbi.nlm.nih.gov/gene/84458 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q96JN0 |
| OMIM ID | 607657 |
| HGNC ID | 29529 |
| Aliases | MLR2, MGC13170, FLJ12529 |
Description
LCOR (Ligand Dependent Co-repressor) encodes a protein that functions as a transcriptional co-repressor for nuclear receptors, including estrogen and thyroid hormone receptors. It recruits histone deacetylases (HDACs) to repress target gene expression. LCOR is implicated in hormone-dependent cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | LCOR represses estrogen receptor target genes; altered expression may contribute to hormone resistance. | ClinVar, COSMIC |
| Prostate cancer | Co-repressor activity on androgen receptor signaling; mutations found in tumor samples. | COSMIC |
| Endometrial cancer | Dysregulation of LCOR expression linked to hormone signaling pathways. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Breast | 6.5 | Low |
| Colon | 7.1 | Low |
| Kidney | 9.3 | Medium |
| Liver | 5.8 | Low |
| Lung | 7.9 | Low |
| Ovary | 8.7 | Medium |
| Prostate | 6.2 | Low |
| Testis | 12.4 | High |
| Uterus | 9.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 10.5 | Estrogen receptor positive; LCOR represses ER targets. |
| LNCaP (prostate cancer) | 7.8 | Androgen receptor positive; LCOR modulates AR signaling. |
| HepG2 (liver cancer) | 6.3 | Low expression; role in metabolism unclear. |
| HEK293 (embryonic kidney) | 9.2 | Model for overexpression studies. |
| K562 (leukemia) | 5.1 | Low expression; not well characterized. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Ter) | Nonsense | 0.02% (COSMIC) | Loss of function; truncation of co-repressor domain. |
| c.742G>A (p.Gly248Arg) | Missense | 0.01% (COSMIC) | Unknown; located in conserved region. |
| c.1234_1235insA (p.Thr412AsnfsTer5) | Frameshift | 0.01% (COSMIC) | Loss of function; premature stop. |
| c.856A>G (p.Ile286Val) | Missense | 0.005% (ClinVar) | Benign; no known functional impact. |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg339Ter, p.Thr412AsnfsTer5) lead to truncated protein lacking co-repressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described in current databases.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nuclear receptor signaling pathway (Reactome: R-HSA-383280)
• Estrogen receptor signaling (Reactome: R-HSA-8939211)
• Androgen receptor signaling (Reactome: R-HSA-5625740)
• HDAC-mediated deacetylation (Reactome: R-HSA-3214847)
Protein Summary
The LCOR protein (UniProt Q96JN0) is a 433-amino acid nuclear co-repressor that interacts with nuclear receptors via its LXXLL motifs and recruits HDAC complexes to repress transcription. It contains a C-terminal domain essential for repression. LCOR is widely expressed, with highest levels in testis. Post-translational modifications include phosphorylation and acetylation, modulating its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| Lcorl Knockout C2C12 Cell Line | EDJ-KQ80 | Mouse | 209707 | Details Get a Quote |
| LCORL Knockout HEK293 Cell Line | EDJ-KQ2536 | Human | 254251 | Details Get a Quote |
| LCOR Knockout HEK293 Cell Line | EDJ-KQ10094 | Human | 84458 | Details Get a Quote |
| LCORL Knockout A-549 Cell Line | EDJ-KQ23169 | Human | 254251 | Details Get a Quote |
| LCORL Knockout HCT 116 Cell Line | EDJ-KQ23170 | Human | 254251 | Details Get a Quote |
| LCORL Knockout HeLa Cell Line | EDJ-KQ23171 | Human | 254251 | Details Get a Quote |
| LCOR Knockout A-549 Cell Line | EDJ-KQ37170 | Human | 84458 | Details Get a Quote |
| LCOR Knockout HeLa Cell Line | EDJ-KQ37172 | Human | 84458 | Details Get a Quote |
| LCOR Knockout HCT 116 Cell Line | EDJ-KQ73410 | Human | 84458 | Details Get a Quote |
