LCN8: Lipocalin 8
A member of the lipocalin family involved in transport of small hydrophobic molecules
Gene Information Card
| Symbol | LCN8 |
|---|---|
| Full Name | lipocalin 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 138402 ncbi.nlm.nih.gov/gene/138402 |
| Ensembl ID | ENSG00000188921 |
| UniProt ID | Q6UWF3 |
| OMIM ID | 611177 |
| HGNC ID | 28497 |
| Aliases | Lcn8, MUP-like lipocalin |
Description
LCN8 (lipocalin 8) is a protein-coding gene belonging to the lipocalin family. Lipocalins are small extracellular proteins that bind and transport hydrophobic molecules such as retinoids, fatty acids, and steroids. LCN8 is expressed in various tissues and may play a role in pheromone transport or immune modulation. The gene is located on chromosome 9q34.3 and encodes a 176-amino acid protein.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | N/A | No cell line expression data in public databases |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • binding (GO:0005488) | • small molecule binding (GO:0036094) |
Protein Summary
The LCN8 protein (UniProt Q6UWF3) is a 176-amino acid lipocalin with a typical beta-barrel structure that binds small hydrophobic ligands. Its exact physiological ligands and functions remain uncharacterized, but it is predicted to participate in transport of lipophilic molecules.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LCN8 Knockout HEK293 Cell Line | EDJ-KQ9409 | Human | 138307 | Details Get a Quote |
| LCN8 Knockout HeLa Cell Line | EDJ-KQ58390 | Human | 138307 | Details Get a Quote |
| LCN8 Knockout A-549 Cell Line | EDJ-KQ66878 | Human | 138307 | Details Get a Quote |
| LCN8 Knockout HCT 116 Cell Line | EDJ-KQ75280 | Human | 138307 | Details Get a Quote |
