LCMT2: Leucine Carboxyl Methyltransferase 2
A protein methyltransferase involved in protein phosphatase 2A (PP2A) methylation and cellular signaling regulation.
Gene Information Card
| Symbol | LCMT2 |
|---|---|
| Full Name | Leucine carboxyl methyltransferase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q15.3 |
| NCBI Gene ID | 9836 ncbi.nlm.nih.gov/gene/9836 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | O60294 |
| OMIM ID | 610476 |
| HGNC ID | 28986 |
| Aliases | LCMT2, PPM2, FLJ20297 |
Description
LCMT2 encodes leucine carboxyl methyltransferase 2, an enzyme that methylates the carboxyl group of leucine residues in target proteins. It is best known for methylating the catalytic subunit of protein phosphatase 2A (PP2A), thereby regulating PP2A activity and its role in cell cycle control, apoptosis, and signal transduction. LCMT2 is widely expressed and its dysregulation is implicated in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered PP2A methylation affects tumor suppressor pathways | COSMIC, literature |
| Neurodegenerative disorders | Impaired PP2A regulation linked to tau hyperphosphorylation | Literature, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.0 | High expression |
| HeLa | 11.2 | Moderate expression |
| K562 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Potential loss of methyltransferase activity |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the catalytic domain may reduce methyltransferase activity, impairing PP2A regulation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • Protein methyltransferase activity | • Leucine carboxyl methyltransferase activity |
| • Methylation | • Protein phosphatase 2A binding |
| • Cytoplasm | • Nucleus |
Pathways
• Protein phosphatase 2A (PP2A) regulation
• Cell cycle
• Tau protein phosphorylation
Protein Summary
Leucine carboxyl methyltransferase 2 (LCMT2) is a 334-amino acid enzyme that catalyzes the methylation of the C-terminal leucine residue of the PP2A catalytic subunit. This modification is essential for PP2A holoenzyme assembly and activity. LCMT2 is localized in the cytoplasm and nucleus, and its expression is regulated during development and in response to cellular stress.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LCMT2 Knockout HEK293 Cell Line | EDJ-KQ6771 | Human | 9836 | Details Get a Quote |
| LCMT2 Knockout A-549 Cell Line | EDJ-KQ31219 | Human | 9836 | Details Get a Quote |
| LCMT2 Knockout HCT 116 Cell Line | EDJ-KQ31220 | Human | 9836 | Details Get a Quote |
| LCMT2 Knockout HeLa Cell Line | EDJ-KQ31221 | Human | 9836 | Details Get a Quote |
