LAT2 Gene (Linker for Activation of T Cells Family Member 2)
Comprehensive genomic and functional analysis of LAT2, a transmembrane adaptor protein involved in immune receptor signaling.
Gene Information Card
| Symbol | LAT2 |
|---|---|
| Full Name | Linker for activation of T cells family member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 7462 ncbi.nlm.nih.gov/gene/7462 |
| Ensembl ID | ENSG00000106366 |
| UniProt ID | Q9GZV4 |
| OMIM ID | 605719 |
| HGNC ID | 15974 |
| Aliases | NTAL, LAB, WBSCR5, WBS15 |
Description
LAT2 (Linker for Activation of T Cells Family Member 2) encodes a transmembrane adaptor protein that is expressed in B cells, mast cells, and natural killer cells. It functions as a negative regulator of immune receptor signaling by competing with LAT for binding to signaling molecules such as GRB2 and PLCG1. LAT2 is involved in the regulation of calcium mobilization and MAP kinase activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No curated evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Medium |
| Whole blood | 6.1 | Low |
| Lung | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (B lymphocyte) | 15.2 | High expression |
| Jurkat (T lymphocyte) | 2.1 | Low expression |
| THP-1 (monocyte) | 4.5 | Medium expression |
| K-562 (erythroleukemia) | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.124G>A (p.Gly42Ser) | missense | <0.01% | No known pathogenic effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Fc epsilon RI signaling pathway (KEGG: hsa04664)
• B cell receptor signaling pathway (KEGG: hsa04662)
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
Protein Summary
LAT2 is a 243-amino acid transmembrane adaptor protein with a short extracellular domain and a long cytoplasmic tail containing multiple tyrosine phosphorylation sites. It is palmitoylated and localizes to lipid rafts. Upon receptor activation, LAT2 is phosphorylated by Src family kinases and recruits SH2 domain-containing proteins, modulating immune signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LAT2 Knockout HEK293 Cell Line | EDJ-KQ6012 | Human | 7462 | Details Get a Quote |
| LAT2 Knockout A-549 Cell Line | EDJ-KQ29621 | Human | 7462 | Details Get a Quote |
| LAT2 Knockout HCT 116 Cell Line | EDJ-KQ29622 | Human | 7462 | Details Get a Quote |
| LAT2 Knockout HeLa Cell Line | EDJ-KQ54747 | Human | 7462 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
