LASP1NB (LASP1 Neighbor) Gene
A novel gene adjacent to LASP1, with limited functional annotation; potential implications in cancer and development.
Gene Information Card
| Symbol | LASP1NB |
|---|---|
| Full Name | LASP1 neighbor |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000267260 |
| UniProt ID | A0A1B0GTV6 |
| OMIM ID | Not available |
| HGNC ID | 53768 |
| Aliases | C17orf82, LASP1 neighbor |
Description
LASP1NB (LASP1 neighbor) is a protein-coding gene located on chromosome 17q12, adjacent to the LASP1 gene. The gene is also known as C17orf82. Its function is not fully characterized, but it is predicted to encode a small protein with potential roles in cellular processes. Expression data suggest it is widely expressed at low levels, with some enrichment in specific tissues. The gene is part of the 17q12 region, which is frequently amplified in certain cancers, including breast and gastric cancer, but the specific role of LASP1NB in these contexts remains to be clarified.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Potential involvement due to 17q12 amplification; LASP1NB may be co-amplified with LASP1 and other genes, but direct mechanistic evidence is lacking. | Inferred from genomic location; no direct studies found. |
| Gastric Cancer | 17q12 amplification is common; LASP1NB may be overexpressed as part of the amplicon, but functional significance is unknown. | Inferred from genomic location; no direct studies found. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Kidney | 1.8 | Low |
| Liver | 1.5 | Low |
| Brain | 1.2 | Low |
| Lung | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 1.5 | Low expression |
| A549 | 1.2 | Low expression |
| MCF7 | 1.0 | Low expression |
| K562 | 0.8 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Not reported | Potential loss of start codon, affecting translation initiation. |
| c.100C>T (p.Arg34Ter) | Nonsense | Not reported | Premature stop codon, likely leading to nonsense-mediated decay. |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported; predicted loss-of-function variants (e.g., nonsense) may lead to reduced protein expression.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular Function: Not yet assigned | • Biological Process: Not yet assigned |
| • Cellular Component: Not yet assigned |
Pathways
• No known pathways associated with LASP1NB.
Protein Summary
The LASP1NB protein is predicted to be a small, uncharacterized protein. Based on its sequence, it may contain a transmembrane domain, but no functional domains have been confirmed. Its expression is low across tissues, and its subcellular localization is unknown. Further studies are needed to elucidate its biological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| LASP1NB Knockout HEK293 Cell Line | EDJ-KQ14028 | Human | 100505576 | Details Get a Quote |
| LASP1NB Knockout A-549 Cell Line | EDJ-KQ43942 | Human | 100505576 | Details Get a Quote |
| LASP1NB Knockout HCT 116 Cell Line | EDJ-KQ43943 | Human | 100505576 | Details Get a Quote |
| LASP1NB Knockout HeLa Cell Line | EDJ-KQ43944 | Human | 100505576 | Details Get a Quote |
