KRT24: Keratin 24 Gene
Structural protein gene involved in epithelial integrity and cancer
Gene Information Card
| Symbol | KRT24 |
|---|---|
| Full Name | Keratin 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 192666 ncbi.nlm.nih.gov/gene/192666 |
| Ensembl ID | ENSG00000167916 |
| UniProt ID | Q2M2I5 |
| OMIM ID | 607925 |
| HGNC ID | 6442 |
| Aliases | K24, CK-24, cytokeratin 24 |
Description
KRT24 (keratin 24) is a protein-coding gene located on chromosome 17q21.2. It encodes a type I intermediate filament keratin expressed in epithelial tissues. Keratins are structural proteins that maintain cell integrity and are involved in tissue differentiation. KRT24 is part of the keratin gene cluster and has been implicated in cancer and epithelial disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered KRT24 expression may affect epithelial cell adhesion and migration, contributing to tumor progression. | NCBI Gene, COSMIC |
| Lung cancer | KRT24 mutations and differential expression observed in lung adenocarcinoma and squamous cell carcinoma. | COSMIC, ClinVar |
| Esophageal cancer | KRT24 upregulation associated with poor prognosis in esophageal squamous cell carcinoma. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Esophagus | 8.3 | Low |
| Breast | 6.1 | Low |
| Lung | 4.7 | Low |
| Cervix | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 5.2 | Low expression |
| MCF7 (breast cancer) | 7.8 | Low expression |
| HaCaT (keratinocyte) | 15.3 | Medium expression |
| HeLa (cervical cancer) | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown effect |
| c.287C>T | missense | <0.1% | Unknown effect |
| c.1045G>A | missense | <0.1% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • structural molecule activity (GO:0005198) | • intermediate filament (GO:0005882) |
| • keratin filament (GO:0045095) | • epithelial cell differentiation (GO:0030855) |
Pathways
• Intermediate filament organization (Reactome: R-HSA-6809371)
• Keratinization (Reactome: R-HSA-6805567)
Protein Summary
Keratin 24 is a type I intermediate filament protein (48 kDa) that heteropolymerizes with type II keratins to form epithelial cytoskeletal networks. It is expressed in stratified epithelia, particularly in skin and esophagus. The protein contributes to mechanical resilience and cell signaling. Alterations in KRT24 expression are linked to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KRT24 Knockout HEK293 Cell Line | EDJ-KQ13975 | Human | 192666 | Details Get a Quote |
| KRT24 Knockout HeLa Cell Line | EDJ-KQ58960 | Human | 192666 | Details Get a Quote |
| KRT24 Knockout A-549 Cell Line | EDJ-KQ67447 | Human | 192666 | Details Get a Quote |
| KRT24 Knockout HCT 116 Cell Line | EDJ-KQ75842 | Human | 192666 | Details Get a Quote |
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