KRT23 Gene - Keratin 23
Type I Cytokeratin Involved in Epithelial Differentiation and Cancer
Gene Information Card
| Symbol | KRT23 |
|---|---|
| Full Name | Keratin 23 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 25984 ncbi.nlm.nih.gov/gene/25984 |
| Ensembl ID | ENSG00000108244 |
| UniProt ID | Q9C075 |
| OMIM ID | 608244 |
| HGNC ID | 6424 |
| Aliases | CK23, K23, cytokeratin 23 |
Description
KRT23 (keratin 23) is a protein-coding gene that belongs to the type I (acidic) keratin family. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. KRT23 is expressed in various epithelial tissues and is involved in cell differentiation and proliferation. It has been implicated in several cancers, including pancreatic, colorectal, and gastric cancers, where it may serve as a diagnostic or prognostic biomarker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Overexpression of KRT23 is associated with tumor progression and poor prognosis. | PMID: 25984338 |
| Colorectal cancer | KRT23 is upregulated in colorectal adenocarcinomas and may promote cell migration. | PMID: 23361059 |
| Gastric cancer | Elevated KRT23 expression correlates with lymph node metastasis and advanced stage. | PMID: 27573527 |
| Hepatocellular carcinoma | KRT23 is differentially expressed in liver cancer tissues compared to normal liver. | PMID: 25602746 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Colon | 8.3 | Medium |
| Stomach | 6.7 | Low |
| Liver | 2.1 | Low |
| Skin | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic) | 15.2 | Overexpressed in pancreatic cancer cell lines |
| HT-29 (colorectal) | 10.8 | Moderate expression |
| MCF7 (breast) | 0.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.1% | Unknown functional impact |
| c.488G>A (p.Arg163Gln) | Missense | <0.1% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in KRT23.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in KRT23.
Dominant Negative (DN)
No dominant-negative mutations reported for KRT23.
View complete mutation data：
Gene Ontology (GO)
| • structural molecule activity (GO:0005198) | • intermediate filament (GO:0005882) |
| • keratin filament (GO:0045095) | • epithelial cell differentiation (GO:0030855) |
| • epidermis development (GO:0008544) |
Pathways
• Intermediate filament organization (Reactome: R-HSA-6809371)
• Keratinization (Reactome: R-HSA-6805567)
Protein Summary
Keratin 23 is a 48.5 kDa type I intermediate filament protein composed of 422 amino acids. It contains a central alpha-helical rod domain flanked by non-helical head and tail domains. KRT23 forms heteropolymers with type II keratins to build cytoskeletal networks in epithelial cells. Its expression is tightly regulated during epithelial differentiation and is frequently altered in epithelial cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KRT23 Knockout HEK293 Cell Line | EDJ-KQ8339 | Human | 25984 | Details Get a Quote |
| KRT23 Knockout HCT 116 Cell Line | EDJ-KQ34348 | Human | 25984 | Details Get a Quote |
| KRT23 Knockout HeLa Cell Line | EDJ-KQ55858 | Human | 25984 | Details Get a Quote |
| KRT23 Knockout A-549 Cell Line | EDJ-KQ64350 | Human | 25984 | Details Get a Quote |
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