KREMEN1
Kringle Containing Transmembrane Protein 1
Gene Information Card
| Symbol | KREMEN1 |
|---|---|
| Full Name | Kringle Containing Transmembrane Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q12.1 |
| NCBI Gene ID | 83999 ncbi.nlm.nih.gov/gene/83999 |
| Ensembl ID | ENSG00000183762 |
| UniProt ID | Q96MU8 |
| OMIM ID | 609898 |
| HGNC ID | 17550 |
| Aliases | KREMEN, KRM1, MGC4615 |
Description
KREMEN1 encodes a transmembrane protein that functions as a receptor for Dickkopf (DKK) proteins, modulating Wnt/β-catenin signaling. It is involved in cell proliferation, differentiation, and embryonic development. The gene is located on chromosome 22q12.1 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of Wnt/β-catenin signaling via KREMEN1-DKK interaction | COSMIC, ClinVar |
| Alzheimer disease | Altered KREMEN1 expression may affect amyloid-β metabolism | NCBI Gene, OMIM |
| Skeletal disorders | Impaired Wnt signaling during bone development | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical cancer cells |
| A549 | 7.5 | Lung cancer cells |
| MCF7 | 11.3 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.01% | Unknown functional effect |
| c.1246G>A (p.Gly416Ser) | Missense | 0.005% | Reported in cancer samples (COSMIC) |
| c.157_158insA | Frameshift | <0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein and impaired Wnt modulation.
Gain of Function (GOF)
Not well characterized; some missense variants may alter DKK binding affinity.
Dominant Negative (DN)
Not reported for KREMEN1.
View complete mutation data：
Gene Ontology (GO)
| • Wnt signaling pathway | • receptor activity |
| • plasma membrane | • protein binding |
| • negative regulation of canonical Wnt signaling pathway |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• DKK-mediated Wnt inhibition
Protein Summary
KREMEN1 is a transmembrane protein with kringle domains that acts as a high-affinity receptor for Dickkopf proteins. It forms a ternary complex with DKK and LRP5/6 to inhibit Wnt/β-catenin signaling, thereby regulating cell fate and proliferation. The protein is expressed in various tissues and is implicated in cancer and neurodegenerative diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KREMEN1 Knockout HEK293T Cell Line | EDJ-KQ165 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout HEK293 Cell Line | EDJ-KQ13972 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout A-549 Cell Line | EDJ-KQ43911 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout HCT 116 Cell Line | EDJ-KQ43912 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout NCI-H1299 Cell Line | EDJ-KZ32 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout RKO Cell Line | EDJ-KZ320 | Human | 83999 | Details Get a Quote |
| KREMEN1 Knockout HeLa Cell Line | EDJ-KQ57519 | Human | 83999 | Details Get a Quote |
