KPNA3 Gene - Karyopherin Subunit Alpha 3
A key nuclear transport receptor involved in nucleocytoplasmic shuttling and linked to cancer and neurological disorders.
Gene Information Card
| Symbol | KPNA3 |
|---|---|
| Full Name | Karyopherin Subunit Alpha 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.3 |
| NCBI Gene ID | 3839 ncbi.nlm.nih.gov/gene/3839 |
| Ensembl ID | ENSG00000102738 |
| UniProt ID | O00505 |
| OMIM ID | 604892 |
| HGNC ID | 6397 |
| Aliases | IPOA4, SRP1, SRP1gamma, hSRP1, RCH1 |
Description
KPNA3 encodes a member of the importin alpha family of proteins, which function as adaptors in nuclear import of proteins containing a classical nuclear localization signal (NLS). The protein mediates the docking of importin beta to the nuclear pore complex and is involved in the transport of transcription factors, cell cycle regulators, and viral proteins. KPNA3 is widely expressed and has been implicated in cancer progression, viral infection, and neurological conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered KPNA3 expression affects nuclear transport of tumor suppressors and oncogenes, promoting proliferation and metastasis. | COSMIC; PubMed studies |
| Viral infections (e.g., HIV, influenza) | KPNA3 mediates nuclear import of viral proteins, facilitating replication. | UniProt; PubMed |
| Neurodevelopmental disorders | KPNA3 variants may disrupt transport of neuronal proteins, affecting brain development. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 11.5 | Medium |
| Brain | 9.3 | Low |
| Liver | 7.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| K562 | 13.2 | Leukemia cell line |
| A549 | 11.8 | Lung cancer cell line |
| HEK293 | 10.4 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown functional impact; reported in ClinVar |
| c.452A>G (p.Asn151Ser) | Missense | <0.1% | Likely benign |
| c.1234G>A (p.Val412Ile) | Missense | <0.1% | Uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein import into nucleus (GO:0006606) | • protein transporter activity (GO:0008565) |
| • nuclear localization sequence binding (GO:0008139) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) |
Pathways
• Nuclear import of NLS-containing proteins (Reactome: R-HSA-168273)
• HIV infection (Reactome: R-HSA-162906)
• Influenza life cycle (Reactome: R-HSA-168254)
Protein Summary
KPNA3 (importin subunit alpha-4) is a 58 kDa protein that functions as an NLS receptor. It contains an N-terminal importin beta-binding domain and C-terminal armadillo repeats that recognize classical NLS motifs. The protein shuttles between nucleus and cytoplasm, playing a critical role in the nuclear import of transcription factors such as NF-κB and STAT1. KPNA3 is overexpressed in several cancers and is a target for antiviral strategies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KPNA3 Knockout HEK293 Cell Line | EDJ-KQ5080 | Human | 3839 | Details Get a Quote |
| KPNA3 Knockout A-549 Cell Line | EDJ-KQ28008 | Human | 3839 | Details Get a Quote |
| KPNA3 Knockout HCT 116 Cell Line | EDJ-KQ28009 | Human | 3839 | Details Get a Quote |
| KPNA3 Knockout HeLa Cell Line | EDJ-KQ26786 | Human | 3839 | Details Get a Quote |
