KLRG2
Killer Cell Lectin Like Receptor G2
Gene Information Card
| Symbol | KLRG2 |
|---|---|
| Full Name | killer cell lectin like receptor G2 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 100144748 ncbi.nlm.nih.gov/gene/100144748 |
| Ensembl ID | ENSG00000205246 |
| UniProt ID | A6NHC0 |
| OMIM ID | 617447 |
| HGNC ID | 37226 |
| Aliases | CLEC15B, MAFA-L, MAFAL |
Description
KLRG2 (killer cell lectin like receptor G2) is a protein-coding gene located on chromosome 7q34. It encodes a transmembrane receptor belonging to the C-type lectin family, expressed primarily on natural killer (NK) cells and a subset of T cells. KLRG2 functions as an inhibitory receptor, binding to cadherins to regulate immune cell activation and cytotoxicity. It plays a role in immune surveillance, tumor immunity, and autoimmune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | KLRG2 expression on NK cells may modulate anti-tumor immunity; altered expression linked to tumor immune evasion. | COSMIC, ClinVar |
| Autoimmune diseases | Dysregulation of KLRG2+ T cells implicated in chronic inflammation and autoimmunity. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.8 | Low |
| Lymph node | 0.6 | Low |
| Bone marrow | 0.5 | Low |
| Blood | 0.4 | Low |
| Lung | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 | 1.2 | NK cell line |
| Jurkat | 0.3 | T cell line |
| HEK293 | 0.1 | Non-immune control |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.215G>A (p.Arg72Gln) | missense | <0.1% | Unknown functional effect |
| c.487C>T (p.Pro163Ser) | missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • carbohydrate binding | • cell adhesion |
| • immune response | • negative regulation of natural killer cell activation |
Pathways
• Natural killer cell mediated cytotoxicity
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein Summary
KLRG2 is a type II transmembrane glycoprotein with an extracellular C-type lectin-like domain. It forms disulfide-linked homodimers and binds to classical cadherins (e.g., E-cadherin, N-cadherin). Upon ligand binding, KLRG2 recruits phosphatases via its immunoreceptor tyrosine-based inhibitory motif (ITIM)-like sequence, leading to inhibition of NK cell and T cell effector functions. It is considered an immune checkpoint receptor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLRG2 Knockout HEK293 Cell Line | EDJ-KQ2790 | Human | 346689 | Details Get a Quote |
| KLRG2 Knockout A-549 Cell Line | EDJ-KQ23720 | Human | 346689 | Details Get a Quote |
| KLRG2 Knockout HeLa Cell Line | EDJ-KQ59806 | Human | 346689 | Details Get a Quote |
| KLRG2 Knockout HCT 116 Cell Line | EDJ-KQ76649 | Human | 346689 | Details Get a Quote |
