KLRC4 Gene - Killer Cell Lectin Like Receptor C4
Comprehensive genomic and functional analysis of KLRC4, a member of the NKG2 family of natural killer cell receptors.
Gene Information Card
| Symbol | KLRC4 |
|---|---|
| Full Name | killer cell lectin like receptor C4 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 8303 ncbi.nlm.nih.gov/gene/8303 |
| Ensembl ID | ENSG00000134545 |
| UniProt ID | Q9NPI6 |
| OMIM ID | 602893 |
| HGNC ID | 6378 |
| Aliases | NKG2-F, NKG2F, CD159f |
Description
KLRC4 (killer cell lectin like receptor C4) is a protein-coding gene located on chromosome 12p13.2. It encodes a member of the NKG2 family of C-type lectin-like receptors, which are primarily expressed on natural killer (NK) cells and subsets of T cells. The protein functions as an activating receptor involved in immune surveillance and cytotoxicity. KLRC4 is closely related to other NKG2 family members and plays a role in regulating innate immune responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 | 0.0 | No detectable expression in this cell line |
| K-562 | 0.0 | No detectable expression in this cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants in COSMIC | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • sugar binding (GO:0005529) | • cell surface receptor signaling pathway (GO:0007166) |
| • integral component of membrane (GO:0016021) |
Pathways
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Reactome: R-HSA-198933)
Protein Summary
The KLRC4 protein (NKG2-F) is a type II transmembrane glycoprotein belonging to the NKG2 family. It contains an extracellular C-type lectin-like domain and a short cytoplasmic tail with no known signaling motifs. The protein is thought to form heterodimers with other NKG2 family members and may modulate NK cell activation. Its precise functional role remains under investigation, but it is implicated in immune recognition and response.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLRC4 Knockout HEK293 Cell Line | EDJ-KQ5491 | Human | 8302 | Details Get a Quote |
| KLRC4 Knockout HCT 116 Cell Line | EDJ-KQ30026 | Human | 8302 | Details Get a Quote |
| KLRC4-KLRK1 Knockout HEK293 Cell Line | EDJ-KQ52488 | Human | 100528032 | Details Get a Quote |
| KLRC4 Knockout HeLa Cell Line | EDJ-KQ54851 | Human | 8302 | Details Get a Quote |
| KLRC4-KLRK1 Knockout HeLa Cell Line | EDJ-KQ60951 | Human | 100528032 | Details Get a Quote |
| KLRC4 Knockout A-549 Cell Line | EDJ-KQ63340 | Human | 8302 | Details Get a Quote |
| KLRC4-KLRK1 Knockout A-549 Cell Line | EDJ-KQ69426 | Human | 100528032 | Details Get a Quote |
| KLRC4-KLRK1 Knockout HCT 116 Cell Line | EDJ-KQ77777 | Human | 100528032 | Details Get a Quote |
