KLK14: Kallikrein Related Peptidase 14
A serine protease involved in skin desquamation, cancer progression, and inflammation
Gene Information Card
| Symbol | KLK14 |
|---|---|
| Full Name | Kallikrein Related Peptidase 14 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.41 |
| NCBI Gene ID | 25847 ncbi.nlm.nih.gov/gene/25847 |
| Ensembl ID | ENSG00000129437 |
| UniProt ID | Q9P0G3 |
| OMIM ID | 606135 |
| HGNC ID | 6368 |
| Aliases | KLK-L6, KLK14, kallikrein-like 6 |
Description
KLK14 encodes a member of the kallikrein subfamily of serine proteases. The encoded preproprotein is proteolytically processed to generate the active enzyme, which is involved in skin desquamation, semen liquefaction, and cancer progression. KLK14 is expressed in the prostate, skin, and other tissues, and its dysregulation is associated with prostate, ovarian, and breast cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | KLK14 overexpression promotes tumor invasion via ECM degradation | PMID: 17363556 |
| Ovarian cancer | Elevated KLK14 expression correlates with poor prognosis | PMID: 16822874 |
| Breast cancer | KLK14 upregulation associated with metastasis | PMID: 19029988 |
| Netherton syndrome | KLK14 dysregulation in skin barrier defects | PMID: 15146421 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Skin | 8.3 | Medium |
| Kidney | 4.1 | Low |
| Breast | 3.2 | Low |
| Ovary | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate) | 15.2 | Androgen-independent line |
| LNCaP (prostate) | 8.7 | Androgen-sensitive |
| MCF-7 (breast) | 5.4 | ER-positive |
| SK-OV-3 (ovary) | 6.1 | High-grade serous |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.233G>A (p.Arg78His) | Missense | <0.01% | Reduced catalytic activity |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect |
| c.614A>G (p.Asn205Ser) | Missense | <0.01% | Altered substrate specificity |
Mutation functional classification
Loss of Function (LOF)
p.Arg78His reduces proteolytic activity
Gain of Function (GOF)
Not reported in KLK14
Dominant Negative (DN)
Not reported in KLK14
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • extracellular region (GO:0005576) |
| • proteolysis (GO:0006508) | • keratinization (GO:0031424) |
| • response to drug (GO:0042493) |
Pathways
• Kallikrein-kinin system
• Prostate cancer – ECM degradation
• Skin barrier formation
Protein Summary
KLK14 is a secreted serine protease of the kallikrein family. The mature enzyme is generated by proteolytic removal of the propeptide and is involved in extracellular matrix remodeling, activation of other proteases, and processing of signaling molecules. It is highly expressed in prostate and skin, and its activity is regulated by serpins and zinc ions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLK14 Knockout HEK293 Cell Line | EDJ-KQ3016 | Human | 43847 | Details Get a Quote |
| KLK14 Knockout HeLa Cell Line | EDJ-KQ56160 | Human | 43847 | Details Get a Quote |
| KLK14 Knockout A-549 Cell Line | EDJ-KQ64649 | Human | 43847 | Details Get a Quote |
| KLK14 Knockout HCT 116 Cell Line | EDJ-KQ73097 | Human | 43847 | Details Get a Quote |
