KLK13: Kallikrein Related Peptidase 13
A serine protease with roles in cancer and skin biology
Gene Information Card
| Symbol | KLK13 |
|---|---|
| Full Name | Kallikrein Related Peptidase 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.41 |
| NCBI Gene ID | 26085 ncbi.nlm.nih.gov/gene/26085 |
| Ensembl ID | ENSG00000167768 |
| UniProt ID | Q9UKR3 |
| OMIM ID | 605505 |
| HGNC ID | 6360 |
| Aliases | KLK-L4, KLK14, KLK-4 |
Description
KLK13 encodes a member of the kallikrein subfamily of serine proteases. The encoded protein is secreted and may be involved in post-translational processing of precursor proteins. KLK13 is differentially expressed in various cancers and has been implicated in tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered expression may influence tumor growth and invasion | NCBI Gene, OMIM |
| Ovarian cancer | Upregulation associated with poor prognosis | NCBI Gene, OMIM |
| Breast cancer | Differential expression linked to hormone receptor status | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 12.5 | Medium |
| Skin | 8.3 | Low |
| Salivary gland | 6.1 | Low |
| Thyroid | 4.2 | Low |
| Testis | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 15.2 | Androgen-independent line |
| LNCaP (prostate cancer) | 9.7 | Androgen-sensitive line |
| MCF-7 (breast cancer) | 5.4 | ER-positive line |
| HeLa (cervical cancer) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.245G>A (p.Arg82His) | Missense | <0.01% | Unknown functional effect |
| c.487C>T (p.Pro163Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • extracellular region (GO:0005576) |
| • proteolysis (GO:0006508) | • negative regulation of endopeptidase activity (GO:0010951) |
Pathways
• KEGG: hsa04610 - Complement and coagulation cascades
• Reactome: R-HSA-1474228 - Degradation of the extracellular matrix
Protein Summary
KLK13 is a secreted serine protease of the kallikrein family. It is synthesized as a preproprotein and undergoes proteolytic processing to generate the active enzyme. The protein is involved in extracellular matrix remodeling and may regulate signaling pathways through proteolytic activation or inactivation of growth factors and receptors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLK13 Knockout HEK293 Cell Line | EDJ-KQ8401 | Human | 26085 | Details Get a Quote |
| KLK13 Knockout HeLa Cell Line | EDJ-KQ55881 | Human | 26085 | Details Get a Quote |
| KLK13 Knockout A-549 Cell Line | EDJ-KQ64371 | Human | 26085 | Details Get a Quote |
| KLK13 Knockout HCT 116 Cell Line | EDJ-KQ72822 | Human | 26085 | Details Get a Quote |
