KLHL25 Gene - Kelch Like Family Member 25 | Function, Disease & Expression

KLHL25 (Kelch Like Family Member 25) is a protein coding gene. It encodes a member of the Kelch-like protein family, characterized by a BTB (Broad-Complex, Tramtrack, and Bric a brac) domain and Kelch repeats. KLHL25 functions as a substrate-specific adaptor for CUL3-based E3 ubiquitin ligase complexes, targeting proteins for ubiquitination and proteasomal degradation. It is involved in cellular processes including protein homeostasis, cell cycle regulation, and stress response. The gene is widely expressed in various tissues.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Ubiquitin mediated proteolysis (KEGG: hsa04120)

• Protein processing in endoplasmic reticulum (KEGG: hsa04141)

KLHL25 is a 587-amino acid protein (UniProt Q5MNZ9) containing an N-terminal BTB domain and six C-terminal Kelch repeats. It acts as a substrate adaptor for CUL3-RING ubiquitin ligase complexes, mediating ubiquitination and degradation of target proteins. The protein is localized in the cytoplasm and cytosol. Its expression is detected in multiple tissues, with highest levels in testis. No disease-associated variants have been reported in ClinVar or OMIM.