KLF18 (Kruppel-like factor 18)
A zinc finger transcription factor with limited functional characterization
Gene Information Card
| Symbol | KLF18 |
|---|---|
| Full Name | Kruppel-like factor 18 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.11 |
| NCBI Gene ID | 285220 ncbi.nlm.nih.gov/gene/285220 |
| Ensembl ID | ENSG00000188389 |
| UniProt ID | Q6ZPJ3 |
| OMIM ID | Not assigned |
| HGNC ID | 18810 |
| Aliases | FLJ38973 |
Description
KLF18 (Kruppel-like factor 18) is a protein-coding gene that belongs to the Kruppel-like factor (KLF) family of zinc finger transcription factors. KLF proteins regulate diverse biological processes including cell proliferation, differentiation, and development. KLF18 is less characterized compared to other KLF family members; its specific functions and downstream targets remain largely unknown. The gene is located on chromosome 19p13.11 and encodes a protein containing C2H2-type zinc finger domains.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association established | Not applicable | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Thyroid | 0.2 | Low |
| Adrenal gland | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.1 | Low expression |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
KLF18 is a predicted zinc finger transcription factor of the Kruppel-like factor family. The protein contains multiple C2H2-type zinc finger domains that mediate sequence-specific DNA binding. Its biological role is not well defined, and no specific target genes or pathways have been experimentally validated. Expression data suggest very low transcript levels across most tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLF18 Knockout HEK293 Cell Line | EDJ-KQ13949 | Human | 105378952 | Details Get a Quote |
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