KLF11 Gene - Kruppel Like Factor 11
Transcriptional regulator in pancreatic beta-cell function and tumor suppression
Gene Information Card
| Symbol | KLF11 |
|---|---|
| Full Name | Kruppel like factor 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p25.1 |
| NCBI Gene ID | 8462 ncbi.nlm.nih.gov/gene/8462 |
| Ensembl ID | ENSG00000172057 |
| UniProt ID | O14901 |
| OMIM ID | 603301 |
| HGNC ID | 6356 |
| Aliases | TIEG2, FKLF, MODY7 |
Description
KLF11 (Kruppel like factor 11) encodes a zinc-finger transcription factor that belongs to the Kruppel-like factor family. It regulates gene expression by binding to GC-rich promoter regions. KLF11 is highly expressed in pancreatic beta-cells where it modulates insulin secretion and cell proliferation. It also functions as a tumor suppressor in various cancers by repressing oncogenic pathways. Mutations in KLF11 are associated with maturity-onset diabetes of the young type 7 (MODY7).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Maturity-onset diabetes of the young type 7 (MODY7) | Loss-of-function mutations impair transcriptional regulation of insulin gene expression, leading to reduced insulin secretion and early-onset diabetes. | ClinVar, OMIM |
| Pancreatic cancer | KLF11 acts as a tumor suppressor; reduced expression or loss-of-function mutations promote cell proliferation and invasion. | COSMIC, NCBI |
| Colorectal cancer | Epigenetic silencing or mutation of KLF11 contributes to tumor progression by dysregulating TGF-beta signaling. | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 28.5 | High |
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Medium |
| Heart | 5.1 | Low |
| Brain | 2.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic cancer) | 15.2 | Endogenous expression |
| HepG2 (liver cancer) | 10.8 | Endogenous expression |
| HEK293 (embryonic kidney) | 6.5 | Endogenous expression |
| MCF7 (breast cancer) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.457C>T (p.Arg153Trp) | Missense | Rare | Loss of DNA-binding activity; associated with MODY7 |
| c.820G>A (p.Glu274Lys) | Missense | Rare | Impaired transcriptional repression; linked to MODY7 |
| c.1012C>T (p.Arg338*) | Nonsense | Very rare | Premature truncation; loss of function |
| c.124_125insG (p.Leu42fs) | Frameshift | Very rare | Loss of function; reported in pancreatic cancer |
Mutation functional classification
Loss of Function (LOF)
Missense and nonsense mutations (e.g., p.Arg153Trp, p.Arg338*) reduce or abolish transcriptional activity, leading to MODY7 and tumor susceptibility.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Some missense mutations (e.g., p.Glu274Lys) may interfere with wild-type KLF11 function, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (Reactome: R-HSA-170834)
• Transcriptional regulation by KLF11 (Reactome: R-HSA-212436)
Protein Summary
KLF11 is a 512-amino acid nuclear protein containing three C2H2-type zinc fingers at the C-terminus that mediate sequence-specific DNA binding. It functions as both a transcriptional repressor and activator depending on context. KLF11 interacts with co-repressors such as Sin3A and HDACs to silence target genes, and with co-activators like p300 to activate transcription. It plays a critical role in pancreatic beta-cell function and acts as a tumor suppressor in gastrointestinal cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KLF11 Knockout HEK293 Cell Line | EDJ-KQ6244 | Human | 8462 | Details Get a Quote |
| KLF11 Knockout A-549 Cell Line | EDJ-KQ30101 | Human | 8462 | Details Get a Quote |
| KLF11 Knockout HCT 116 Cell Line | EDJ-KQ30102 | Human | 8462 | Details Get a Quote |
| KLF11 Knockout HeLa Cell Line | EDJ-KQ30103 | Human | 8462 | Details Get a Quote |
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