KIF4A
Kinesin Family Member 4A
Gene Information Card
| Symbol | KIF4A |
|---|---|
| Full Name | kinesin family member 4A |
| Gene Type | protein coding |
| Chromosomal Location | Xq13.1 |
| NCBI Gene ID | 24137 ncbi.nlm.nih.gov/gene/24137 |
| Ensembl ID | ENSG00000131495 |
| UniProt ID | O95235 |
| OMIM ID | 300521 |
| HGNC ID | 6389 |
| Aliases | KIF4, KIF4B, FLJ12552 |
Description
KIF4A encodes a member of the kinesin-4 family of microtubule-based motor proteins. It plays a critical role in mitotic chromosome condensation, spindle organization, and cytokinesis. KIF4A is a component of the chromosomal passenger complex (CPC) and is involved in regulating the localization of Aurora B kinase. The protein also functions in neuronal development and DNA repair.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression promotes cell proliferation and migration; associated with poor prognosis | COSMIC, ClinVar |
| Primary microcephaly | Loss-of-function mutations impair mitotic progression | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 38.2 | High |
| Bone marrow | 15.1 | Medium |
| Lymph node | 12.8 | Medium |
| Brain | 6.5 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 45.3 | Cervical cancer cell line |
| A549 | 32.7 | Lung cancer cell line |
| K562 | 28.9 | Leukemia cell line |
| MCF7 | 22.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | 0.02% | Unknown functional effect |
| c.567_568del (p.Glu190fs) | Frameshift | 0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations lead to truncated protein and loss of motor activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule motor activity | • ATP binding |
| • microtubule binding | • chromosome segregation |
| • mitotic spindle organization | • cytokinesis |
Pathways
• Cell Cycle
• Mitotic
• Chromosomal Passenger Complex (CPC) pathway
• Kinesins
Protein Summary
KIF4A is a 1232-amino acid protein with an N-terminal motor domain, a central coiled-coil region, and a C-terminal cargo-binding domain. It functions as a plus-end-directed microtubule motor and is essential for proper chromosome dynamics during cell division. The protein localizes to the mitotic spindle and midbody.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF4A Knockout HEK293 Cell Line | EDJ-KQ3646 | Human | 24137 | Details Get a Quote |
| KIF4A Knockout A-549 Cell Line | EDJ-KQ25607 | Human | 24137 | Details Get a Quote |
| KIF4A Knockout HCT 116 Cell Line | EDJ-KQ25608 | Human | 24137 | Details Get a Quote |
| KIF4A Knockout HeLa Cell Line | EDJ-KQ25609 | Human | 24137 | Details Get a Quote |
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