KIF2B
Kinesin Family Member 2B
Gene Information Card
| Symbol | KIF2B |
|---|---|
| Full Name | kinesin family member 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 84643 ncbi.nlm.nih.gov/gene/84643 |
| Ensembl ID | ENSG00000141560 |
| UniProt ID | Q8N4N8 |
| OMIM ID | 608322 |
| HGNC ID | 29423 |
| Aliases | KIF2B, KIF2B_HUMAN, MGC138290 |
Description
KIF2B encodes a member of the kinesin-13 family of microtubule depolymerases. The protein localizes to the mitotic spindle and is involved in microtubule dynamics during cell division, particularly in chromosome segregation and spindle assembly. It is expressed in multiple tissues and has been implicated in cancer and neurodevelopmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of KIF2B expression alters microtubule dynamics, promoting aneuploidy and tumor progression | COSMIC, ClinVar |
| Neurodevelopmental disorders | Loss-of-function mutations may impair neuronal migration and differentiation | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression in cervical cancer cell line |
| HEK293 | 9.8 | Moderate expression in embryonic kidney cells |
| A549 | 7.4 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339*) | Nonsense | <0.1% | Loss of function; truncation of protein |
| c.1420G>A (p.Glu474Lys) | Missense | <0.1% | Unknown; predicted damaging by SIFT |
| c.1876_1877insA | Frameshift | <0.1% | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated or absent protein, impairing microtubule depolymerase activity.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Not reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • ATP binding |
| • microtubule depolymerase activity | • mitotic spindle organization |
| • cell division |
Pathways
• Mitotic spindle assembly
• Microtubule dynamics
Protein Summary
KIF2B is a 706-amino acid protein belonging to the kinesin-13 family. It contains a motor domain that uses ATP hydrolysis to depolymerize microtubules from their ends, crucial for proper chromosome segregation during mitosis. The protein is localized to the spindle poles and kinetochores.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF2B Knockout HEK293 Cell Line | EDJ-KQ10148 | Human | 84643 | Details Get a Quote |
| KIF2B Knockout HeLa Cell Line | EDJ-KQ57628 | Human | 84643 | Details Get a Quote |
| KIF2B Knockout A-549 Cell Line | EDJ-KQ66126 | Human | 84643 | Details Get a Quote |
| KIF2B Knockout HCT 116 Cell Line | EDJ-KQ74551 | Human | 84643 | Details Get a Quote |
