KIF26A
Kinesin Family Member 26A
Gene Information Card
| Symbol | KIF26A |
|---|---|
| Full Name | kinesin family member 26A |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 26153 ncbi.nlm.nih.gov/gene/26153 |
| Ensembl ID | ENSG00000166762 |
| UniProt ID | Q9ULI4 |
| OMIM ID | 613354 |
| HGNC ID | 20223 |
| Aliases | FLJ20036, KIAA1270 |
Description
KIF26A is a member of the kinesin superfamily of microtubule-based motor proteins. It is involved in intracellular transport and may play a role in cell migration and adhesion. The gene is located on chromosome 14q32.33 and encodes a protein of 1,814 amino acids.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hirschsprung disease | Loss-of-function mutations in KIF26A impair enteric neuron migration, leading to aganglionosis | PMID: 20346441 |
| Neuroblastoma | KIF26A overexpression correlates with poor prognosis and MYCN amplification | PMID: 23542218 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Colon | 8.7 | Low |
| Kidney | 6.2 | Low |
| Testis | 15.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 14.5 | Neuroblastoma cell line |
| HEK293 | 9.8 | Embryonic kidney |
| HeLa | 7.3 | Cervical carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.01% | p.Arg412Cys; likely benign |
| c.4567_4568del | Frameshift | <0.01% | p.Leu1523fs; loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, impairing microtubule binding or motor activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule motor activity | • ATP binding |
| • microtubule binding | • intracellular transport |
Pathways
• Kinesin-mediated transport
• Microtubule-based movement
Protein Summary
KIF26A is a kinesin motor protein that moves along microtubules, likely transporting cargoes involved in neuronal development and cell migration. It contains an N-terminal motor domain and a long coiled-coil stalk.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF26A Knockout HEK293 Cell Line | EDJ-KQ8439 | Human | 26153 | Details Get a Quote |
| KIF26A Knockout HCT 116 Cell Line | EDJ-KQ34555 | Human | 26153 | Details Get a Quote |
| KIF26A Knockout HeLa Cell Line | EDJ-KQ34556 | Human | 26153 | Details Get a Quote |
| KIF26A Knockout A-549 Cell Line | EDJ-KQ64377 | Human | 26153 | Details Get a Quote |
