KIF24: Kinesin Family Member 24
A microtubule-based motor protein involved in ciliogenesis and cell cycle regulation
Gene Information Card
| Symbol | KIF24 |
|---|---|
| Full Name | kinesin family member 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p13.3 |
| NCBI Gene ID | 347240 ncbi.nlm.nih.gov/gene/347240 |
| Ensembl ID | ENSG00000186625 |
| UniProt ID | Q5T7B8 |
| OMIM ID | 615381 |
| HGNC ID | 29426 |
| Aliases | FLJ12529, MGC35130 |
Description
KIF24 is a member of the kinesin superfamily of microtubule-based motor proteins. It plays a critical role in the regulation of ciliogenesis by depolymerizing microtubules at the mother centriole, thereby suppressing primary cilia formation in cycling cells. KIF24 is also implicated in cell cycle progression and has been associated with various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of KIF24 may promote uncontrolled cell proliferation by altering cilia-dependent signaling pathways. | COSMIC; literature review |
| Breast cancer | Overexpression of KIF24 has been observed in breast cancer cell lines, potentially contributing to tumorigenesis. | COSMIC; NCBI Gene |
| Lung cancer | KIF24 mutations and altered expression reported in lung cancer samples. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 6.1 | Low |
| Brain | 4.3 | Low |
| Liver | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.0 | Cervical cancer cell line; high expression |
| MCF7 | 10.2 | Breast cancer cell line; moderate expression |
| A549 | 8.5 | Lung cancer cell line; moderate expression |
| HEK293 | 6.0 | Embryonic kidney; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Premature truncation; likely loss of function |
| c.567G>A (p.Val189Met) | Missense | <0.1% | Unknown significance; predicted benign |
| c.890_891insA | Frameshift | <0.1% | Frameshift; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg412*, c.890_891insA) are predicted to result in loss of KIF24 function, potentially disrupting cilia regulation.
Gain of Function (GOF)
No documented gain-of-function mutations in KIF24.
Dominant Negative (DN)
No evidence for dominant-negative effects in KIF24.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cilium assembly (Reactome: R-HSA-5617833)
• Microtubule-dependent transport (Reactome: R-HSA-983189)
Protein Summary
KIF24 encodes a kinesin motor protein that localizes to the mother centriole and uses its ATPase activity to depolymerize microtubules, thereby preventing primary cilium formation in proliferating cells. The protein contains an N-terminal motor domain and a C-terminal domain involved in centriolar targeting. KIF24 is essential for cell cycle-dependent cilia disassembly and its dysregulation is linked to cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF24 Knockout HEK293 Cell Line | EDJ-KQ13938 | Human | 347240 | Details Get a Quote |
| KIF24 Knockout A-549 Cell Line | EDJ-KQ43841 | Human | 347240 | Details Get a Quote |
| KIF24 Knockout HCT 116 Cell Line | EDJ-KQ43842 | Human | 347240 | Details Get a Quote |
| KIF24 Knockout HeLa Cell Line | EDJ-KQ43843 | Human | 347240 | Details Get a Quote |
