KIF20B
Kinesin Family Member 20B: A Mitotic Kinesin Involved in Cytokinesis and Cell Proliferation
Gene Information Card
| Symbol | KIF20B |
|---|---|
| Full Name | kinesin family member 20B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.31 |
| NCBI Gene ID | 9585 ncbi.nlm.nih.gov/gene/9585 |
| Ensembl ID | ENSG00000138182 |
| UniProt ID | Q96Q89 |
| OMIM ID | 605381 |
| HGNC ID | 29572 |
| Aliases | MPHOSPH1, MPP1, CT90, KRP3, M-phase phosphoprotein 1 |
Description
KIF20B (kinesin family member 20B) encodes a member of the kinesin superfamily of microtubule-associated motor proteins. This protein is involved in mitotic progression, specifically in cytokinesis and cell division. It localizes to the midbody and is essential for the final separation of daughter cells. KIF20B is also implicated in vesicle transport and cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression promotes cell proliferation and tumor growth; involved in cytokinesis defects | NCBI Gene, COSMIC |
| Primary microcephaly | Loss-of-function mutations impair mitotic spindle organization and cytokinesis | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Bone marrow | 12.8 | Medium |
| Lymph node | 10.5 | Medium |
| Spleen | 9.1 | Low |
| Brain | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.4 | High expression |
| K562 | 14.7 | Medium expression |
| A549 | 12.1 | Medium expression |
| MCF7 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.274C>T (p.Arg92*) | Nonsense | <0.1% | Loss of function; associated with microcephaly |
| c.1234G>A (p.Glu412Lys) | Missense | 0.2% | Unknown functional impact; reported in cancer |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg92*) lead to truncated protein and loss of motor activity, impairing cytokinesis.
Gain of Function (GOF)
Not well characterized; overexpression in tumors may confer proliferative advantage.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule motor activity | • ATP binding |
| • microtubule binding | • cytokinesis |
| • mitotic cell cycle | • cell division |
| • midbody |
Pathways
• Kinesins
• Cell Cycle
• Mitotic
• Cytokinesis
Protein Summary
KIF20B is a 958-amino acid kinesin motor protein that contains an N-terminal motor domain, a central coiled-coil region, and a C-terminal cargo-binding domain. It functions as a plus-end-directed microtubule motor, essential for cytokinesis by transporting vesicles to the midbody. Its expression is cell cycle-regulated, peaking during mitosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF20B Knockout HEK293 Cell Line | EDJ-KQ2269 | Human | 9585 | Details Get a Quote |
| KIF20B Knockout A-549 Cell Line | EDJ-KQ21282 | Human | 9585 | Details Get a Quote |
| KIF20B Knockout HCT 116 Cell Line | EDJ-KQ22608 | Human | 9585 | Details Get a Quote |
| KIF20B Knockout HeLa Cell Line | EDJ-KQ22609 | Human | 9585 | Details Get a Quote |
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