KIF20A
Kinesin Family Member 20A
Gene Information Card
| Symbol | KIF20A |
|---|---|
| Full Name | kinesin family member 20A |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 10112 ncbi.nlm.nih.gov/gene/10112 |
| Ensembl ID | ENSG00000112984 |
| UniProt ID | O95235 |
| OMIM ID | 605664 |
| HGNC ID | 9781 |
| Aliases | MKLP2, RAB6KIFL |
Description
KIF20A (kinesin family member 20A) encodes a motor protein belonging to the kinesin superfamily. It is involved in mitotic spindle assembly, chromosome segregation, and cytokinesis. KIF20A interacts with RAB6 and is essential for Golgi apparatus dynamics and vesicle transport during cell division. Overexpression is observed in various cancers and correlates with poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes proliferation and migration | NCBI Gene, COSMIC |
| Lung cancer | Upregulation associated with tumor progression | NCBI Gene, COSMIC |
| Hepatocellular carcinoma | High expression linked to poor survival | NCBI Gene, COSMIC |
| Pancreatic cancer | KIF20A drives mitotic defects and aneuploidy | COSMIC, ClinVar |
| Colorectal cancer | Amplification and overexpression reported | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 38.2 | High |
| Bone marrow | 15.7 | Medium |
| Lymph node | 12.4 | Medium |
| Spleen | 8.9 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 45.3 | Cervical cancer cell line |
| A549 | 32.1 | Lung cancer cell line |
| MCF7 | 28.7 | Breast cancer cell line |
| HepG2 | 22.5 | Liver cancer cell line |
| K562 | 18.9 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | 0.02% | Unknown functional impact |
| c.567_568insA (p.Glu190fs) | Frameshift | <0.01% | Loss of function |
| c.890A>G (p.Asn297Ser) | Missense | 0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Glu190fs) predicted to truncate the protein and impair motor activity.
Gain of Function (GOF)
Not well documented; missense variants may alter microtubule binding but evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule motor activity | • ATP binding |
| • microtubule binding | • mitotic spindle organization |
| • cytokinesis | • Golgi organization |
| • vesicle-mediated transport |
Pathways
• Cell Cycle
• Mitotic
• Kinesins
• RAB6-mediated vesicle transport
Protein Summary
KIF20A is a 890-amino acid kinesin motor protein with an N-terminal motor domain, a coiled-coil stalk, and a C-terminal cargo-binding domain. It localizes to the midbody during cytokinesis and is required for abscission. It also mediates RAB6-dependent transport from the Golgi to the cell periphery.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KIF20A Knockout HEK293 Cell Line | EDJ-KQ3504 | Human | 10112 | Details Get a Quote |
| KIF20A Knockout A-549 Cell Line | EDJ-KQ25310 | Human | 10112 | Details Get a Quote |
| KIF20A Knockout HCT 116 Cell Line | EDJ-KQ25311 | Human | 10112 | Details Get a Quote |
| KIF20A Knockout HeLa Cell Line | EDJ-KQ25312 | Human | 10112 | Details Get a Quote |
