KCTD2
Potassium Channel Tetramerization Domain Containing 2
Gene Information Card
| Symbol | KCTD2 |
|---|---|
| Full Name | Potassium Channel Tetramerization Domain Containing 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q14.1 |
| NCBI Gene ID | 23510 ncbi.nlm.nih.gov/gene/23510 |
| Ensembl ID | ENSG00000149311 |
| UniProt ID | Q14681 |
| OMIM ID | 613681 |
| HGNC ID | 18233 |
| Aliases | KIAA0176, BTBD27 |
Description
KCTD2 (Potassium Channel Tetramerization Domain Containing 2) is a protein-coding gene that encodes a member of the KCTD family. The protein contains a BTB/POZ domain and a potassium channel tetramerization domain. It is involved in protein-protein interactions and may play a role in cellular signaling and development. KCTD2 is widely expressed in various tissues, with notable levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 17.2 | Medium |
| Testis | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 10.2 | Medium expression |
| K562 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No significant mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • protein homodimerization activity | • identical protein binding |
| • potassium channel activity |
Pathways
• No specific pathways annotated
Protein Summary
The KCTD2 protein is a 289-amino acid polypeptide that contains a BTB/POZ domain and a potassium channel tetramerization domain. It is predicted to localize to the cytoplasm and nucleus. The protein may function as a transcriptional regulator or adaptor in signaling complexes, though its precise biological role remains to be fully elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KCTD20 Knockout HEK293 Cell Line | EDJ-KQ9035 | Human | 222658 | Details Get a Quote |
| KCTD21 Knockout HEK293 Cell Line | EDJ-KQ13914 | Human | 283219 | Details Get a Quote |
| KCTD20 Knockout A-549 Cell Line | EDJ-KQ35480 | Human | 222658 | Details Get a Quote |
| KCTD20 Knockout HCT 116 Cell Line | EDJ-KQ35481 | Human | 222658 | Details Get a Quote |
| KCTD20 Knockout HeLa Cell Line | EDJ-KQ35482 | Human | 222658 | Details Get a Quote |
| KCTD21 Knockout A-549 Cell Line | EDJ-KQ43777 | Human | 283219 | Details Get a Quote |
| KCTD21 Knockout HCT 116 Cell Line | EDJ-KQ43778 | Human | 283219 | Details Get a Quote |
| KCTD21 Knockout HeLa Cell Line | EDJ-KQ43779 | Human | 283219 | Details Get a Quote |
| KCTD2 Knockout HEK293 Cell Line | EDJ-KQ51112 | Human | 23510 | Details Get a Quote |
| KCTD2 Knockout HeLa Cell Line | EDJ-KQ55755 | Human | 23510 | Details Get a Quote |
| KCTD2 Knockout A-549 Cell Line | EDJ-KQ64253 | Human | 23510 | Details Get a Quote |
| KCTD2 Knockout HCT 116 Cell Line | EDJ-KQ72699 | Human | 23510 | Details Get a Quote |
