KCNK7
Potassium Two Pore Domain Channel Subfamily K Member 7
Gene Information Card
| Symbol | KCNK7 |
|---|---|
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 10089 ncbi.nlm.nih.gov/gene/10089 |
| Ensembl ID | ENSG00000173338 |
| UniProt ID | Q9Y2U5 |
| OMIM ID | 603940 |
| HGNC ID | 6281 |
| Aliases | K2P7.1, TASK-3, TASK3 |
Description
KCNK7 encodes a member of the two-pore-domain potassium channel family. The protein forms a homodimeric or heterodimeric channel that mediates background potassium currents, contributing to the regulation of resting membrane potential and cellular excitability. Expression is predominantly in the central nervous system and heart.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Lung | 2.1 | Not detected |
| Liver | 0.5 | Not detected |
| Kidney | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.0 | Neuronal cell line |
| HEK293 | 0.8 | Low expression |
| HepG2 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown significance |
| c.200C>T | missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • potassium ion transmembrane transport | • voltage-gated potassium channel activity |
| • protein homodimerization activity | • membrane |
Pathways
• Potassium channels
Protein Summary
KCNK7 (K2P7.1) is a 374-amino-acid protein with four transmembrane segments and two pore-forming domains. It functions as a background potassium channel, sensitive to extracellular pH and volatile anesthetics. The channel is involved in setting the resting membrane potential in neurons and cardiac myocytes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KCNK7 Knockout HEK293 Cell Line | EDJ-KQ6893 | Human | 10089 | Details Get a Quote |
| KCNK7 Knockout HeLa Cell Line | EDJ-KQ55315 | Human | 10089 | Details Get a Quote |
| KCNK7 Knockout A-549 Cell Line | EDJ-KQ63798 | Human | 10089 | Details Get a Quote |
| KCNK7 Knockout HCT 116 Cell Line | EDJ-KQ72257 | Human | 10089 | Details Get a Quote |
