KCNK15
Potassium Two Pore Domain Channel Subfamily K Member 15
Gene Information Card
| Symbol | KCNK15 |
|---|---|
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 60598 ncbi.nlm.nih.gov/gene/60598 |
| Ensembl ID | ENSG00000125846 |
| UniProt ID | Q9H427 |
| OMIM ID | 607368 |
| HGNC ID | 6280 |
| Aliases | TASK-5, K2p15.1, TASK5 |
Description
KCNK15 encodes a member of the two-pore-domain potassium channel (K2P) family, specifically the TASK-5 (TWIK-related acid-sensitive K+ channel 5) subunit. This channel is characterized by four transmembrane segments and two pore-forming domains. KCNK15 is primarily expressed in the central nervous system and adrenal gland. Unlike other TASK channels, TASK-5 does not form functional homomeric channels in heterologous expression systems and may require heteromerization with other K2P subunits to produce functional currents. The gene is located on chromosome 20q13.12 and spans approximately 8.5 kb.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebellum) | 5.2 | Low |
| Adrenal gland | 4.8 | Low |
| Testis | 3.1 | Not detected |
| Heart | 1.0 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 2.1 | Low expression |
| HEK293 | 0.3 | Not detected |
| HeLa | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Potassium channels (Reactome: R-HSA-1296071)
• Transmembrane transport of small molecules (Reactome: R-HSA-382551)
Protein Summary
The KCNK15 protein (TASK-5) is a 330-amino acid potassium channel subunit with two pore domains and four transmembrane helices. It is predicted to form a dimeric channel that conducts potassium ions across the plasma membrane. TASK-5 is structurally similar to TASK-1 and TASK-3 but does not produce functional homomeric channels in standard expression systems. It may modulate channel activity through heteromerization. The protein is predominantly expressed in neuronal tissues and the adrenal gland.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KCNK15 Knockout HEK293 Cell Line | EDJ-KQ13896 | Human | 60598 | Details Get a Quote |
| KCNK15 Knockout HeLa Cell Line | EDJ-KQ43756 | Human | 60598 | Details Get a Quote |
| KCNK15 Knockout A-549 Cell Line | EDJ-KQ65487 | Human | 60598 | Details Get a Quote |
| KCNK15 Knockout HCT 116 Cell Line | EDJ-KQ73925 | Human | 60598 | Details Get a Quote |
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